| 岩藻多糖对2型糖尿病的预防作用 |
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| 引用本文： | 程绍远,张继国,刘曼,韩梅,岳旺,鞠传霞.岩藻多糖对2型糖尿病的预防作用[J].泰山医学院学报,2011,32(1):28-29. |
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| 作者姓名： | 程绍远 张继国 刘曼 韩梅 岳旺 鞠传霞 |
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| 作者单位： | 1. 青岛大学医学院,山东,青岛,266021
2. 泰山医学院,山东,泰安,271016 |
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| 摘 要： | 目的研究岩藻多糖对链脲佐菌素诱导实验性2型糖尿病大鼠的预防作用。方法建立2型糖尿病大鼠动物模型,预防给药岩藻多糖（600mg/kg、400mg/kg、200mg/kg）5周后,测定大鼠、空腹血糖、血脂和血清胰岛素水平。结果高脂高糖饮食联合腹腔注射小剂量链脲佐菌素（30 mg/kg）可诱导大鼠2型糖尿病模型。岩藻多糖可降低大鼠空腹血糖,提高基础胰岛素水平,升高胰岛素敏感指数,改善胰岛素抵抗。并能降低血清胆固醇、甘油三酯、低密度脂蛋白胆固醇含量,升高高密度脂蛋白胆固醇水平。结论岩藻多糖对实验性2型糖尿病的发生有预防作用。
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| 关 键 词： | 岩藻多糖 2型糖尿病 血糖 胰岛素 胰岛素抵抗 |
Preventive effect of fucoidan of type 2 diabetes mellitus |
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| CHENG Shao-yuan,ZHANG Ji-guo,LIU Man,HAN Mei,YUE Wang,JU Chuan-xia.Preventive effect of fucoidan of type 2 diabetes mellitus[J].Journal of Taishan Medical College,2011,32(1):28-29. |
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| Authors: | CHENG Shao-yuan ZHANG Ji-guo LIU Man HAN Mei YUE Wang JU Chuan-xia |
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| Affiliation: | 1(1.Medical College of Qingdao University,Qingdao 266021,China;2 Taishan Medical College,Taian 271016,China) |
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| Abstract: | Objective: To study the preventive effects of fucoidan on rats of type 2 diabetes mellitus.Methods: Type 2 diabetic rats were rendered by feeding high-energy diet together with injection of streptozotocin(STZ).The changes of fasting blood glucose(FBG),fasting insulin(FINS),insulin sensitivity,serum lipids fat were observed.Results: The fucoidan reduced FBG,FINS,total cholesterol,triglyceride and low density lipoprotein cholesterol,and increased insulin sensitivity index and contents of high density lipoproteincholesterol.Conclusion: The fucoidan has preventive effects on type 2 diabetes. |
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| Keywords: | fucoidan type 2 diabetes mellitus blood glucose insulin insulin resistance |
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