| 甘草锌口服剂型在兔体内药物动力学研究 |
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| 引用本文： | 孙殿甲,崔玉琴.甘草锌口服剂型在兔体内药物动力学研究[J].新疆医科大学学报,1986(4). |
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| 作者姓名： | 孙殿甲 崔玉琴 |
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| 作者单位： | 新疆医学院药学系药剂教研室，新疆医学院药学系药剂教研室 |
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| 摘 要： | 选用缝康家兔为受试对象,给药剂量O.5g。耳静脉定时取血,分离血清,用原子吸收光谱法测定锌浓度。按单室模型用计算机进行数据处理,求得各剂型的动力学参数。由半衰期和曲线下面积表明,片剂具有生物利用度较高、体内作用时间较长的特点。
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| 关 键 词： | 锌 原子吸收光谱法 药物动力学参数 |
Pharmacokinectic Study on Zinc Licorice in Rabbits |
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| Sun Dianjia.Pharmacokinectic Study on Zinc Licorice in Rabbits[J].Journal of Xinjiang Medical University,1986(4). |
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| Authors: | Sun Dianjia |
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| Affiliation: | Sun Dianjia,Department of Pharmacy,Xinjiang Medical College |
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| Abstract: | 0.5 gm of zinc licorice was orally given to healthy rabbits The blood was collected from the vein of the ear and serum was seperated. Concentration of zinc was determined by AAS. According to one compartment mode, the observed data were handled by computer. The pharmacokinetic parameter of three dosage forms of the drugs used was obtained. Through the biological half life (t1/2) and the area under the blood level-time curve (AUC), the results indicates that the tablet has the characteristic of higher bioaviobility and longer time of effects in rabbits. |
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| Keywords: | zinc AAS pharmacokinetic parameter |
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