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| 新疆3种植物提取物对二肽基肽酶Ⅳ活性的影响 | |
| 引用本文： | 杨珍珍,王雪花,王烨,毛新民,韩雪,易金阳,王丽凤,马晓丽,李琳琳.新疆3种植物提取物对二肽基肽酶Ⅳ活性的影响[J].新疆医科大学学报,2012,35(6):721-724. |
| 作者姓名： | 杨珍珍 王雪花 王烨 毛新民 韩雪 易金阳 王丽凤 马晓丽 李琳琳 |
| 作者单位： | 1. 新疆医科大学基础医学院药理学教研室,乌鲁木齐,830011 2. 新疆伊犁新源县人民医院,新疆,伊宁,835800 3. 新疆医科大学,中医学院,乌鲁木齐,830011 4. 新疆医科大学,基础医学院生理学教研室,乌鲁木齐,830011 5. 新疆医科大学,分析测试中心,乌鲁木齐,830011 |
| 摘 要： | 目的探讨葫芦巴、鹰嘴豆、石榴皮水提物对二肽基肽酶Ⅳ(DPP-4)体外活性的影响。方法采用DPP-4体外抑制模型,对新疆具有降糖作用的葫芦巴、鹰嘴豆、石榴皮3种植物水提取物进行筛选,选择抑二肽素A(IIe-pro-IIe)作为阳性对照药物,比较3种水提物的IC50差异。结果 IIe-pro-IIe的IC50为(0.01±0.01)mg/mL,葫芦巴水提物IC50为(0.03±0.01)mg/mL,石榴皮水提物IC50为(0.19±0.13)mg/mL,鹰嘴豆水提物IC50为(0.09±0.07)mg/mL。结论葫芦巴、石榴皮、鹰嘴豆的水提取物对DPP-4有一定程度的抑制作用。 |
| 关 键 词： | 新疆降糖植物 提取物 二肽基肽酶Ⅳ抑制剂 |
Effect of dipeptidyl peptidase Ⅳ in 3 extracts from plants of Xinjiang |
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| YANG Zhen-zhen , WANG Xue-hua , WANG Ye , MAO Xin-min , HAN Xue , YI Jin-yang , WANG Li-feng , MA Xiao-li , LI Lin-lin.Effect of dipeptidyl peptidase Ⅳ in 3 extracts from plants of Xinjiang[J].Journal of Xinjiang Medical University,2012,35(6):721-724. | |
| Authors: | YANG Zhen-zhen WANG Xue-hua WANG Ye MAO Xin-min HAN Xue YI Jin-yang WANG Li-feng MA Xiao-li LI Lin-lin |
| Affiliation: | 1(1Department of Pharmacology,Xinjiang Medical University,Urumqi 830011,China, 2Xinyuan People′s Hospital of Xinjiang Yining,Yining 835800,China,3College of Traditional Chinese Medicine,4Department of Physiology,5Department of Analysis and Testing Center, Xinjiang Medical University,Urumqi 830011,China) |
| Abstract: | Objective To study the effect of dipeptidyl peptidase Ⅳ in extracts from Trigonella foenum-graecum L.Cicer arietinum L.Punica Granatum L.Methods The inhibitory effects of these 3 extracts to dipeptidyl peptidase Ⅳ activity were investigated by in vitro enzymatic method and IIe-Pro-IIe was used as positive reference substance.Comparison of 3 kinds of water extracts of IC50.Results IIe-pro-IIe IC50 was 0.01 mg/mL.Trigonella foenum-graecum L.water extraction IC50 was 0.03mg/mL,Punica Granatum L.water extraction IC50 was 0.19 mg/mL,Cicer arietinum L.water extraction IC50 was 0.09 mg/mL.Conclusion The 3 extracts of Xinjiang antidiabetic plant showed obviously inhibitory action against dipeptidyl peptidase Ⅳ activity.Trigonella,Pomegranate husk,Cicer arinum L.water extraction to dipeptidyl peptidase Ⅳ have different degrees of inhibition. |
| Keywords: | antidiabetic plant of Xinjiang extracts dipeptidyl peptidase Ⅳ inhibitors |
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