冠心病患者血清胆红素、尿酸、超敏C反应蛋白水平变化及临床意义

目的研究冠心病患者血清胆红素（Bil）、尿酸（UA）及超敏C反应蛋白（hs-CRP）水平变化及临床意义。方法对96例冠心病患者稳定型心绞痛（SAP）组46例、不稳定型心绞痛（UAP）组30例、急性心肌梗死（AMI）组20例]血清总胆红素（TBil）、直接胆红素（DBil）、UA、hs-CRP水平进行检测,并与正常对照组的30例健康受试者进行比较分析。结果冠心病患者组血清TBil（9.96±1.05）μmol/L]、DBil（2.69±0.32）μmol/L]水平显著低于正常对照组,UA（376.52±40.21）μmol/L]、hs-CRP（11.35±1.26）mg/L]水平显著高于正常对照组,差异均有统计学意义（均P〈0.05）;SAP、UAP组血清TBil（11.21±1.12）、（9.86±1.04）μmol/L]、DBil（3.59±0.36）、（2.98±0.32）μmol/L]水平均显著高于AMI组,UA（292.05±29.12）、（427.41±41.98）μmol/L]、hs-CRP（6.31±0.64）、（10.67±1.14）mg/L]水平均显著低于AMI组,差异均有统计学意义（均P〈0.05）;SAP组血清UA、hs-CRP水平显著低于UAP组,差异均有统计学意义（均P〈0.05）;TBil、DBil与UA、hs-CRP均呈显著负相关（r=-0.61、-0.59、-0.63、-0.60,均P〈0.05）。结论检测冠心病患者血清TBil、DBil、UA、hs-CRP水平对患者疾病预测及治疗具有重要的临床意义。

Clinical significance of detecting serum levels of serum bilirubin, uric acid, hs-CRP in patients with coronary heart disease

Objective To study the clinical significance of detecting serum levels of serum Bil,UA,hs-CRP in patients with coronary heart disease(CHD).Methods The serum levels of TBil,DBil,UA,hs-CRP were detected in 96 patients(46 patients with stable angina,30 patients with unstable angina,20 patients with acute myocardial infarction),and compared with those of 30 healthy subjects in the control group.Results The serum levels of TBil (9.96±1.05) μmol/L],DBil (2.69±0.32) μmol/L] in the CHD group were significantly lower than those in the control group(all P<0.05),and the serum levels of UA (376.52±40.21)μmol/L],hs-CRP (11.35±1.26)mg/L] were significantly higher than those in the control group(all P<0.05).The serum levels of TBil (11.21±1.12),(9.86±1.04)μmol/L],DBil (3.59±0.36),(2.98±0.32)μmol/L] in the SAP group and the UAP group were significantly higher than those in the AMI group(all P<0.05),and the serum levels of UA (292.05±29.12),(427.41±41.98)μmol/L],hs-CRP (6.31±0.64),(10.67±1.14)mg/L] in the SAP group and the UAP group were significantly lower than those in the AMI group(all P<0.05).The serum levels of UA,hs-CRP in the SAP group were significantly lower than those in the UAP group(all P<0.05).The serum levels of TBil,DBil were negatively correlated with UA,hs-CRP(r=-0.61,-0.59,-0.63,-0.60,all P<0.05).Conclusion The detection of serum levels of TBil,DBil,UA,hs-CRP play an important role in disease prediction and treatment of patients with CHD.