神经节苷脂联合依达拉奉对急性脑梗死患者神经功能及血液流变学的影响

目的探讨神经节苷脂联合依达拉奉治疗急性脑梗死（ACI）的临床效果。方法将80例ACI患者随机分为对照组（40例）和观察组（40例）,对照组患者给予依达拉奉,观察组患者在此基础上加用神经节苷脂注射液。治疗前后对两组患者进行神经功能缺损评分,并观察血液流变学变化。结果两组患者神经功能缺损评分均较治疗前明显降低,差异有统计学意义（P〈0.05）;治疗第7天,观察组患者神经功能缺损评分低于观察组,差异有统计学意义（P〈0.05）。两组患者1/S全血黏度切变率、200/S全血黏度切变率、血浆黏度及纤维蛋白原水平较治疗前有明显改善,差异有统计学意义（P〈0.05）,但观察组患者上述指标改善更明显（P〈0.05）。结论神经节苷脂联合依达拉奉治疗ACI,具有更好地改善患者血液流变学、促进其缺损神经功能康复的作用。

Effect of Ganglioside combined with Edaravone on nerve function and hemorheology in patients with acute cerebral infarction

Objective To investigate the effect of Ganglioside combined with Edaravone on nerve function and hemorheology in patients with acute cerebral infarction(ACI).Methods 80 patients with ACI were randomly divided into control group(40 cases) and the observation group(40 cases),the patients of control group were treated with Edaravone,and the patients of observation group were treated with Ganglioside combined Edaravone;the neurological deficit of the two groups before and after treatment was evaluated,and the changes of hemorheology were observed.Results The neurological function deficit scores in patients of two groups were significantly decreased compared with pre-treatment,the difference was statistically significant(P<0.05);7 days of treatment,the neurological function in patients of observation group was lower than the control group,the difference was statistically significant(P<0.05);the 1/S shear rate of whole blood viscosity,200/S shear rate of whole blood viscosity,plasma viscosity and fibrinogen in patients of two groups was better than before treatment,the difference was statistically significant(P<0.05),which the indexes above in the observation group were improved much better than the control group(P<0.05).Conclusion Ganglioside and Edaravone can better improve hemorheology and promote the role of defects in neurological rehabilitation in patients with ACI.