| Separation of chlorobenzyltetrahydroberberine enantiomers by capillary electrophoresis and their chiral pharmacokinetic studies in rabbits |
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| 作者姓名： | 范国荣 胡晋红 林海 黄文龙 李珍 沈意翔 |
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| 作者单位： | Fan Guorong; Hu Jinhong; Lin Mei;Huang Wenlong; Li Zhen; Shen Yixiang Department of Clinical Pharmacology，Changhai Hospital，hand Military Medical University，Shanghai，200433; College of Pharmacy，China Pharmaceutical University，Naming，210009 |
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| 基金项目： | Supported by National Natural Science foundation of China, No. 39700181 |
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| 摘 要： | In the pharmaceutical industry, aPPnailnately 40%Of Pharmaceutical compounds are chilal, while oaly about12 % of the formulations used are one enantiomeric formof the ~endc miXture Ij. Different enantiomers oftenhave different biological and pharmacological properties.The safety and efficacy of chiral drug Products requiressuitable stereoselective analyhcal methods for the separation Of enantiomers. Capillmp electIDPhoresis (CE) was afavorable melhod in this field, compared with high perf…
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Separation of chlorobenzyltetrahydroberberine enantiomers by capillary electrophoresis and their chiral pharmacokinetic studies in rabbits |
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| Fan Guorong, Hu Jinhong, Lin Mei,Huang Wenlong, Li Zhen, Shen Yixiang.Separation of chlorobenzyltetrahydroberberine enantiomers by capillary electrophoresis and their chiral pharmacokinetic studies in rabbits[J].Journal of Medical Colleges of PLA(China),2000(2). |
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| Authors: | Fan Guorong Hu Jinhong Lin Mei Huang Wenlong Li Zhen Shen Yixiang |
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| Affiliation: | Fan Guorong, Hu Jinhong, Lin Mei,Huang Wenlong, Li Zhen, Shen Yixiang Department of Clinical Pharmacology,Changhai Hospital,hand Military Medical University,Shanghai,200433, College of Pharmacy,China Pharmaceutical University,Naming,210009 |
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| Abstract: | |
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| Keywords: | chlorobenzyltetrahydroberberine enantiomeric separation capillary electriogiresis chiral pharmacokinetics |
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