| 异质性成人型多囊肾基因定位研究 |
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| 引用本文： | 宁志芬,刘国印.异质性成人型多囊肾基因定位研究[J].承德医学院学报,1999,16(2):95-98. |
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| 作者姓名： | 宁志芬 刘国印 |
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| 作者单位： | [1]承德医学院生物教研室 [2]中国医学科学院基础医学研究所 |
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| 摘 要： | 目的：对国内首次发现的异质性成人型多囊肾家系进行基因定位的研究。方法：采用家系分析、核型分析、聚合酶链－限制性片段长度多态Ｒ，连锁分析和Ｌｏｄ Ｓｃｏｒｅ值计算等分子生物学及细胞生物学的技术和方法。结果：排除了Ｄ２Ｓ４４、ＡｐｏＢ、Ｄ１０Ｓ２８，Ｄ１７Ｓ２５４位点上不存在异质性ＡＰＫＤ的致病基因。结论：此结果为进一步深入研究此基因提供了有价值的资料。
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| 关 键 词： | 成人型 多囊肾病 异质性 基因定位 |
STUDY ON GENE LOCATION IN A FAMILY OF HETEROGENEOUS ADULT POLYCYSTIC
KIDNET DISEASE |
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| Ning,Zhifen et al.STUDY ON GENE LOCATION IN A FAMILY OF HETEROGENEOUS ADULT POLYCYSTIC
KIDNET DISEASE[J].Journal of Chengde Medical College,1999,16(2):95-98. |
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| Authors: | Ning Zhifen |
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| Affiliation: | Ning Zhifen et al Department of Medical Biology |
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| Abstract: | objective:To locate the heterogeneity gene of adult polycystic kidney
disease(APKD)discovered first in our country from a family.Methods:molecular biologic
and genetic technique and methods were used,such as PCR RFLP,pedigree
analysis,karyotype analysis and calculation of Lod Score value.Results:We excluded the
linkage between heterogeneity gene and D2S44,ApoB,D10S28,and D17S254(17q22
q24).Conclusion:The result provided valuble information for further study on this research
area. |
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| Keywords: | adult polycystic kidney disease heterogenity gene location |
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