| 大黄对雌性幼年大鼠血清GnRH、LH、FSH、P、E2水平的影响 |
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| 引用本文： | 刘梦杰,佟继铭,宋素英,万慧杰,卢宁,张树峰.大黄对雌性幼年大鼠血清GnRH、LH、FSH、P、E2水平的影响[J].承德医学院学报,2015(2):102-104. |
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| 作者姓名： | 刘梦杰 佟继铭 宋素英 万慧杰 卢宁 张树峰 |
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| 作者单位： | 1. 河北省中药研究与开发重点实验室/承德医学院中药研究所,河北承德,067000;2. 河北联合大学中医学院 |
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| 摘 要： | 目的：：观察大黄水提物对雌性幼年大鼠血清促性腺激素释放激素(GnRH)、黄体生成素(LH)、卵泡刺激素(FSH)、孕酮(P)、雌二醇(E2)水平的影响。方法：4周龄雌性SD大鼠20只，随机分为正常对照组和大黄水提物2.0g/kg组，每组10只，连续灌胃给药30天。采用ELISA法检测各组大鼠血清GnRH、LH、FSH、P、E2的水平。结果：与正常对照组大鼠比较，大黄水提物2.0g/kg组大鼠GnRH、P、E2激素水平明显降低(P＜0.05)，LH、FSH激素水平明显升高(P＜0.05)。结论：大黄水提物可明显影响雌性幼年大鼠下丘脑-垂体-卵巢轴的激素水平。
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| 关 键 词： | 大黄水提物 雌性幼年大鼠 GnRH LH FSH P E2 |
INFLUENCES OF RHUBARB ON GNRH,LH, FSH,P AND E2 LEVEL IN SERUM OF YOUNG FEMALE RATS |
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| Affiliation: | LIU Meng-jie;TONG Ji-ming;SONG Su-ying;Hebei Key Laboratory of Research and Exploitation of Traditional Chinese Medicine/ Institute of Chinese Materia Medica,Chengde Medical College; |
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| Abstract: | ABSTRACT]Objective: To observe the inlfuences of aqueous extract of Rhubarb on gonadotrophin releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (P) and estradiol (E2) level in serum of young female rats.Methods:20 4-week female SD rats were randomly divided into normal control group and Rhubarb aqueous extract (2.0g/kg) group, with 10 rats in each group. The GnRH, LH, FSH, P and E2 level in serum of rats were detected by ELISA after the rats were lavaged with Rhubarb aqueous extract for 30-day.Results: Compared with rats in normal control group, the GnRH, P and E2 level in serum of rats in Rhubarb aqueous extract group decreased obviously (P<0.05); LH and FSH level increased obviously (P<0.05).Conclusions: Rhubarb aqueous extract can inlfuence the hormone level of hypothalamic-hypophyscal-ovarian axis of young female rats obviously. |
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| Keywords: | Aqueous extract of Rhubarb Young female rats Gonadotrophin releasing hormone (GnRH) Luteinizing hormone (LH) Follicle-stimulating hormone (FSH) Progesterone (P) Estradiol (E2) |
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