血清甲状腺素检测判断慢性重型乙型肝炎预后的价值

目的：探讨慢性重型病毒性乙型肝炎（CSHB）患者血清甲状腺激素水平变化与预后的关系。方法应用放射免疫法检测73例慢性重型乙肝患者（观察组）与80例健康体检者（对照组）的血清甲状腺激素水平进行分折,并比较慢性重型乙肝患者死亡组与存活组血清甲状腺激素水平变化。结果观察组血清T3、T4水平显著低于对照组（均P〈0.01）,rT3水平显著高于对照组（P〈0.01）,两组TSH水平比较无显著性差异（P〉0.05）；慢性重型乙肝患者死亡者血清T3、T4水平显著低于存活组（均P〈0.05）,rT3水平显著高于存活组（P〈0.05）。结论血清甲状腺激素水平检测对判断慢性重型乙型肝炎预后有重大价值。

The value of serum thyroxine in the prognosis of chronic severe hepatitis B

Objective To investigate the relationship between chronic severe hepatitis B （CSHB） serum thyroid hor-mone levels and prognosis. Methods By radioimmunoassay on 73 cases of chronic severe hepatitis B patients （study group） serum thyroid hormone levels,and 80 healthy subjects （control group）were sub-fold, and compared the group of death with chronic serum thyroid hormone levels in patients with severe hepatitis B survivors changes. Results serum T3,T4 levels of observation group were significantly lower than the control group（both P〈0.01）,rT3 levels were sig-nificantly higher （P〈0.01）, there was no significant difference （P〉 0.05） in TSH level of two groups; chronic severe hepatitis B patients who died in serum T3,T4 levels were significantly lower than the survival group （both P〈0.05）,rT3 levels were significantly higher than survival group（P〈0.05）. Conclusion The detection of serum thyroid hormone levels to determine the prognosis of chronic severe hepatitis B has significant value.