首页 | 官方网站   微博 | 高级检索  
     

半胱氨酰白三烯受体与脑损伤关系的研究进展
引用本文:张丽慧,赵建波,王艳芳,张纬萍,魏尔清.半胱氨酰白三烯受体与脑损伤关系的研究进展[J].浙江大学学报(医学版),2008,37(3):315-320.
作者姓名:张丽慧  赵建波  王艳芳  张纬萍  魏尔清
作者单位:1. 杭州师范大学基础医学院药理教研室,浙江,杭州,310036
2. 浙江大学医学院药理学系,浙江,杭州,310058
基金项目:国家自然科学基金 , 浙江省自然科学基金
摘    要:近年来发现,半胱氨酰白三烯CysLT1和CysLT2受体参与整体水平脑缺血和脑外伤后神经损伤.CysLT1受体调节脑缺血后血脑屏障通透性增高、血管性脑水肿,介导星形胶质细胞增殖及炎症反应;CysLT2受体调节脑缺血后AQP4表达增加、细胞性脑水肿,介导星形胶质细胞损伤;新发现的GPR17也与脑缺血损伤有密切关系.加深CysLT受体在脑损伤及神经保护中作用的认识,将为CysLT受体作为药物靶点筛选和开发防治脑损伤的药物提供新的途径.

关 键 词:半胱氨酰白三烯受体  脑疾病  脑损伤  半胱氨酰白三烯  受体调节  脑损伤  关系  研究进展  brain  injury  leukotriene  receptors  advance  药物靶点  防治  开发  筛选  认识  作用  神经保护  加深  脑缺血损伤  星形胶质细胞损伤  细胞性  表达
文章编号:1008-9292(2008)03-0315-06
修稿时间:2008年1月18日

Research advance in cysteinyl leukotriene receptors with brain injury
ZHANG Li-hui,ZHAO Jian-bo,WANG Yan-fang,ZHANG Wei-ping,WEI Er-qing.Research advance in cysteinyl leukotriene receptors with brain injury[J].Journal of Zhejiang University(Medical Sciences),2008,37(3):315-320.
Authors:ZHANG Li-hui  ZHAO Jian-bo  WANG Yan-fang  ZHANG Wei-ping  WEI Er-qing
Affiliation:Department of Pharmacology, School of Basic Medicine, Hangzhou Normal University, Hangzhou 310036, China. lihuizhang002@sina.com
Abstract:OBJECTIVE: Based on the findings recently reported, cysteinyl leukotriene receptors, both CysLT (1) and CysLT(2) receptors, are involved in the ischemic and traumatic brain injury in vivo. CysLT(1)receptor regulates the increased permeability of blood-brain barrier and the related vasogenic brain edema, astrocyte proliferation, and inflammatory responses after brain ischemia; while CysLT(2)receptor regulates AQP4 expression and the related cytotoxic brain edema, and astrocyte injury. A new subtype of CysLT receptor, GPR17, is also involved in brain ischemic injury. The roles of CysLT receptors in brain injury or neuroprotection from the injury should be further understood. This understanding is necessary to accelerate the screening and development of the new drugs for the prevention and treatment of brain injury with the receptors as therapeutic targets.
Keywords:Cysteinyl leukotriene receptor  Brain diseases  Brain injuries  
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司    京ICP备09084417号-23

京公网安备 11010802026262号