特发性炎症性肌病自身抗体的研究进展

多发性肌炎(PM)和皮肌炎是自身免疫性疾病,以对称性四肢近端肌无力为特征性表现,皮肌炎除了肌肉受累,还有特征性的皮肤受累表现。近年研究发现,PM和皮肌炎患者体内存在多种自身抗体,包括肌炎特异性自身抗体和肌炎相关性自身抗体,并发现多种新型的自身抗体与疾病的表现有密切联系,临床上通过对这些自身抗体的检测可帮助诊断疾病及判断预后。

Research Progress of Idiopathic Inflammatory Myopathy Autoantibody

Polymyositis and dermatomyositis （PM/DM） are connective tissue disease characterized bysymmetric proximal muscle weakness of the limbs, and approximately 50% of the patients may be accompa-nied by myalgia or muscle tenderness. DM has the characteristic of skin involvement in addition to muscleinvolvement. Recent research showed that there are a variety of autoantibodies in patients with PM/DM,including myositis specific autoantibodies and myositis associated autoantibodies, and found that several newautoantibodies are closely associated with the manifestations of the disease. Clinical detection of theseautoantibodies can help diagnose the disease and predict the prognosis.