动脉粥样硬化相关性疾病血清胆红素与血脂检测结果分析

目的:探讨血清胆红素浓度与四种动脉粥样硬化( AS)性疾病的关系。方法:观察组分为四组,单纯性高血压组、冠心病组、糖尿病组、脑梗死组,对照组为同年龄段健康查体者,检测空腹血清总胆红素、直接胆红素、总胆固醇、三酰甘油、高密度脂蛋白胆固醇,低密度脂蛋白胆固醇,计算间接胆红素,并对检测结果进行统计学分析。结果:与对照组比较,观察组中直接胆红素均有所下降,但差异无显著统计学意义( P>0 .0 5 ) ,总胆红素与间接胆红素除脑梗死组外,其他各组均明显降低( P<0 .0 5 ) ;除脑梗死组HDL - C与对照组无显著差异外,其他观察组血脂各指标与对照组比较均有显著统计学差异( P<0 .0 5 ) ,且糖尿病组三酰甘油及冠心病组低密度脂蛋白胆固醇与对照组比较有极显著统计学差异( P<0 .0 1 )。结论:高血压、冠心病、脑梗死、糖尿病等动脉粥样硬化相关性疾病血清胆红素浓度有不同程度降低,其中,间接胆红素降低更明显,提示可将胆红素水平作为AS患者体内氧化活性增加的一个临床监测指标

Analysis of serum bilirubin and lipids level in patients with atherosclerotic diseases

Objective:To explore the relationship between serum bilirubin concentrtion and four kinds of atherosclerotic diseases.Methods: Serum bilirubin and lipids were measured and compared between control group and observering group which was divided into four categories:pure hypertension,CHD,DM,cerebral infarction. Results: Compared with control group ,serum level of direct bilirubin was lower without significant difference in all observering groups( P >0.05),but total bilirubin, indirect bilirubin and HDL-C was distinctly lower( P <0.05) except cerebral infarction group;TC,TG,LDL-C in all observering groups were obviously higher ( P <0.05),even to the extent that TG in DM group and LDL-C in CHD group increased remarkably( P <0.01).Conclusion: Serum bilirubin level in four kinds of Atherosclerotic diseases was decresed significantly ,especially indirect bilirubin.Detection of serum bilirubin level could become a useful index for judging the oxidation activity in AS patients.