惊厥患儿血清、脑脊液中神经元特异性烯醇化酶的临床意义

目的 探讨血清与脑脊液中神经元特异性烯醇化酶(NSE)水平在惊厥中的临床意义。方法选择105例惊厥患儿,根据病因分为病毒性脑炎组(33例)、热性惊厥组(37例)和轻度胃肠炎伴发婴幼儿良性惊厥组(35例),以入院时怀疑有神经系统疾病,最后经各种检查除外神经系统疾病的儿童(25例)作为对照组。采用电化学发光免疫分析技术测定各组血清与脑脊液中NSE水平。结果惊厥发作后病毒性脑炎组患儿血清与脑脊液中NSE水平明显升高,显著高于热性惊厥组、轻度胃肠炎伴发婴幼儿良性惊厥组及对照组(P<0.01),3组间NSE水平的差异无统计学意义(P>0.05)。结论病毒性脑炎惊厥发作后血清和脑脊液中NSE水平与脑损伤严重程度密切相关,可作为早期判断惊厥性脑损伤的客观指标之一。

The Clinical Significance of Neuron-Specific Enolase in Serum and Cerebrospinal Fluid of Children with Convulsion

Objective To explore the levels of neuron-specific enolase (NSE) in serum and cerebrospinal fluid (CSF) of children with convulsion and their clinical significances.MethodsOne hundred and five children with convulsion were enrolled.According to the clinical diagnosis,the children were divided into viral encephalitis (VE) group (33 cases),febrile convulsion (FC) group (37 cases),and benign infantile convulsions associated with mild gastreenteritis (BICE) group (35 cases).Serum and CSF were collected within 24~48 h after convulsive seizures.The children,who were suspected neurological diseases,and finally except for neurological diseases by various examinations,were selected as the control group (25cases) to collect serum and cerebrospinal fluid.Serum and CSF were collected before surgery.The levels of NSE in serum and CSF were detected by electrochemiluminescence immunoassay.ResultThe levels of NSE in serum and CSF of VE group were increased significantly,and were much higher than in serum and CSF of FC group,BICE group and control group (P<0.01).The difference among FC group,BICE group and control group was not statistically significant (P>0.05).ConclusionsThe levels of NSE in serum and CSF of children with viral encephalitis after convulsive seizures,have a close correlation with the severity of brain injury,which may serve as objective indicators in the early prediction of brain injury.