前列腺增生症与前列腺癌微血管密度计数的比较

目的测定正常前列腺（NP）、前列腺增生症（BPH）、前列腺癌（Pc）三者中及前列腺癌不同病理分级、临床分期中微血管密度计数，比较微血管密度计数在它们中的差别。方法应用链霉菌素抗生物蛋白-过氧化酶方法，用CD34单克隆抗体对正常前列腺、前列腺增生症、前列腺癌行免疫组织化学染色，采用Weinder方法对CD34标记的微血管密度进行定量计数。结果微血管密度在正常前列腺、前列腺增生症、前列腺癌三组中计数分别为15．10±2．33、27．63±3．67、60．20±15．53；微血管密度在PC高、中、低分化细胞病理学分级三组中的计数分别为44．30±3．90、56．10±4．61、81．47±5．90；微血管密度在前列腺癌临床分期A、B、C、D期四组中的计数分别为48．67±7．2、54．79±10．81、72．00±16．31、65．73±15．44，各组差异均具有显著性（P〈0．01）。结论微血管密度计数在前列腺癌高于前列腺增生症、前列腺增生症高于正常前列腺，微血管密度计数在前列腺癌随着细胞病理学分级的降低和临床分期的升高而增加。

The Experimental Comparison of Microvessel Density in Normal Prostate、Benign Prostatic Hyperplasia and Prostate Cancer

Objective To evaluate microvessel density(MVD) count in normal prostate(NP),benign prostatic hyperplasia(BPH),and prostate cancer(PC),as well as in different grading both pathological and clinical system.The aim of our work is to explore significance of MVD in the development of BPH and PC as well as their possible application to clinical diagnosis. Methods According to pathological grade,PC were divided into three groups: 16 high-grade,19 moderate-grade,15 low-grade.According to clinical stage,PC were divi...