汉族医学生抑郁现状与生活事件、5-羟色胺转运体基因多态性的相关性研究

目的：分析汉族医学生的抑郁现状,探讨具体生活事件和5-羟色胺转运体启动区（5-HTTLPR）基因多态性与抑郁情绪的关系,为医学生抑郁症的干预与治疗提供理论依据。方法：采用青少年生活事件量表与抑郁自评量表收集某高校431名医学生资料,应用聚合酶链式反应（PCR）扩增技术测定151例具有抑郁情绪者和280例无抑郁情绪者的5-HTTLPR基因多态性,分析5-HTTLPR对抑郁情绪的影响。结果：被调查的医学生中有35%的人表现为不同程度的抑郁;在发生率超过50%的生活事件中,学习负担重、被人误会或错怪、同学或好友发生纠纷、生活习惯明显变化、不喜欢上学等事件与抑郁情绪间差异有统计学意义（P〈0.05）;在6项生活事件因子中,人际关系因子、健康适应因子与抑郁情绪间差异有统计学意义（P〈0.05）;5-HTTLPR基因型频率在各抑郁情绪组间差异有统计学意义（P〈0.05）。结论：医学生存在很大程度的抑郁现象,多为轻度抑郁;抑郁现象的发生与大学生一些具体生活事件存在一定的关联;5-HTTLPR基因多态性对医学生抑郁情绪有影响。

Research on the Correlation of Depression Status quo of Medical Students with Their Life Events and Gene Polymorphism of Serotonin Transporter

Objective：To provide a theoretical basis for the intervention and treatment of medical students＆#39;depression through the analysis of depression status quo of medical students of Han nationality and investigation of the correlation among concrete life events ,serotonin transporter promoter polymorphism （5-HTTLPR） and depression emotion .Methods：The data of 431 medi_cal students from a medical college were collected through their filling in juvenile life events scale and depression self -evaluation scale .DNA Polymerase Chain reaction （PCR） was employed to evaluate serotonin transporter promoter polymorphism （5-HT_TLPR） in 151 identified students with depression emotion and the rest 280 identified ones without depression emotion ,with the effect of 5-HTTLPR on depression emotion analyzed by chi -squared test .Results：35% of the medical students surveyed were found showing the depression of varying degrees .Of the life events with an occurrence rate of over 50% ,such events as heavy study burden ,being misunderstood or wronged ,dispute between classmates or good friends ,evident changes in the lifestyle ,and objection to attending school were significantly related to the depression emotion （ P〈0 .05） .Of 6 life events factors ,the inter_personal relationship factor and the health adaptation factor were significantly related to depression emotion （ P〈0 .05） .There was significant difference in genotype frequency of 5-HTTLPR among depression emotion groups （the value of χ2 was 8 .163 and 0 .017 ,respectively） .Conclusion：A huge percentage of medical students suffer from depression ,the mild depression mainly , the occurrence of which is related to some concrete life events to certain degree .Serotonin transporter promoter polymorphism （5-HTTLPR） also to certain degree contributes to depression emotion of medical students .