环磷酰胺治疗狼疮性肾炎60例临床分析

目的:探讨环磷酰胺(CTX)治疗狼疮性肾炎的疗效及其安全性.方法:选择我院自2009年2月至2010年12月住院治疗的狼疮性肾炎患者120例,随机分为治疗组和对照组,每组各60例,对照组患者服用泼尼松片,治疗组在对照组基础上使用环磷酰胺冲击治疗,并对临床效果观察分析.结果:经过治疗,治疗组的总有效率为95.0%,对照组...

Clinical Analysis of 60 Cases Lupus Nephritis Treated with Cyclophosphamide

Objective： To explore the effect and safety of cyclophosphamide on lupus nephritis（LN）.Method： 120 cases LN were divided into treatment group and control group,each with 60 cases.who were treated in our hospital from Feb.2009 to Dec.2010.The patients in control group took prednisone tablets,while the patients were given cyclophosphamide pulse on the basic treatment of control group,And then observed the clinical effect.Result： The total effective rate was 95.0% and 65.0% in treatment group and control group respectively.There＇s significant difference（P0.05）.The urinary protein of 24 hours and Scr were decreased significantly in both groups after treatment,esp.in treatment group.While the level of C3 and C4 in both groups were increased obviously,esp.C3 in treatment group（P0.05）.The side effect were gastrointestinal reactions,leukopenia and alopecia in both groups.Conclusion： It＇s effective to treat lupus nephritis with cyclophosphamide,with less recurrence.