帕金森病非运动症状临床特点研究

目的:全面评估帕金森病(Parkinson disease,PD)患者非运动症状,总结男性和女性PD患者、青年型和老年型PD患者非运动症状临床特征的异同。方法:应用统一PD评定量表第三部分和H-Y分级评估PD患者的运动功能和疾病严重程度;应用非运动症状评定量表全面评估PD患者各项非运动症状的发生率。结果:本研究纳入38例为青年型PD,62例为老年型PD。女性PD患者更易出现紧张、疼痛等症状,而男性更易出现注意力缺乏及忘记做事情等症状;泌尿系统症状等非运动症状在男性PD患者更常见。老年型PD患者胃肠道症状及泌尿系统症状发生率明显高于青年型PD患者,且吞咽困难、便秘、夜尿增多、嗅觉减退等症状在老年型PD患者更常见。结论:非运动症状在PD患者中十分常见,男女PD患者合并不同的非运动症状,老年型PD患者合并更多的非运动症状。

The clinical features of non-motor symptoms in Parkinson disease patients

Objective:To overall assess Non-motor symptoms (NMS)in Parkinson diseases (PD)patients and to study the differences of NMS between male and female as well as early-onset PD (EOPD)and late-onset PD (LOPD)patients.Methods:The U-nified PD Rating Scale part Ⅲ (UPDRS Ⅲ)and Hoehn and Yahr (H&Y)stage were accessed with motor function and disease severi-ty.The incidence of non-motor symptoms in PD patients was assessed with the non-motor symptom rating scale.Results:38 EOPD and 62 LOPD were included in our study.The “feeling of nervousness”and “pain”symptoms were more prevalent in female patients than in male patients while “attention deficit”,“forgetting to do things”symptoms were more prevalent in male patients than in female pa-tients.Urinary symptoms and other non-motor symptoms are more common in male patients.The NMS of gastrointestinal and urinary do-mains were more common in LOPD patients than in EOPD patients,whereas “difficulty swallowing”,“constipation”,“nocturia”and“taste or smell”symptoms were more common in LOPD patients.Conclusion:NMS was common in PD population.Male and female PD patients had different non-motor symptoms.LOPD patients were likely to suffer more NMS than EOPD patients.