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伴精神异常神经性皮炎患者血清神经营养因子及白介素-6水平检测
引用本文:万永山,李玉萍,刘爱梅.伴精神异常神经性皮炎患者血清神经营养因子及白介素-6水平检测[J].中原医刊,2013(23):86-87.
作者姓名:万永山  李玉萍  刘爱梅
作者单位:河南省安阳市第一人民医院皮肤科,455000
摘    要:目的探讨血清脑源性神经营养因子(BDNF)、血清胶南源性神经营养因子(GDNF)和白介素-6(IL-6)在神经性皮炎患者发病过程中的影响机制。方法对50例伴有和没有精神异常神经性皮炎患者进行血清BD—NF、GDNF和IL-6酶联免疫吸附法(ELISA)检测。结果伴有精神异常的神经性皮炎患者BDNF和GDNF血清含量明显降低;IL-6血清含量显著升高,差异有统计学意义(P〈0.05)。结论BDNF,GDNF和IL-6可能在神经性皮炎患者发病过程中起重要作用。

关 键 词:心身疾病  神经性皮炎  脑源性神经营养因子  胶质源性神经营养因子  白细胞介素-6

Neurotrophic factor and IL-6 levels in serum of neurodermatitis patients with mental disorder
WAN Yong-shan,LI Yu-ping,LIU Ai-mei.Neurotrophic factor and IL-6 levels in serum of neurodermatitis patients with mental disorder[J].Central Plains Medical Journal,2013(23):86-87.
Authors:WAN Yong-shan  LI Yu-ping  LIU Ai-mei
Affiliation:.( Department of Dermatology, the First People' s Hospital of An-yang , Anyang 455000, China)
Abstract:Objective To investigate the impact mechanism of BDNF,GDNF and IL-6 in the neuro-dermatitis patients. Methods The serum levels of BDNF, GDNF and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA) in each 25 cases of neurodermatitis patients accompanied and not mental disor-der. Results BDNF and GDNF serum levels decreased significantly in the neurodermatitis patients with men- tal disorder; IL-6 serum levels increased significantly, the difference was statistically significant. Conclusions BDNF,GDNF and IL-6 may have important role in the pathogenesis of patients with neurodermatitis.
Keywords:Psychosomatic diseases  Neurodermatitis  Brain-derived neurotrophic factor  Glial-derived neurotrophic factor  Interleukin-6
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