抗肿瘤药物诱导的机化性肺炎的研究进展

药物引起的肺损害越来越受到重视，其中最常见的表现是间质性肺疾病（ILD），已有不少研究探讨药物诱导的ILD（DIILD）的诊断、治疗及预后，但DIILD中仍有很多亚型，根据病理不同可分为普通型间质性肺炎、非特异性间质性肺炎、机化性肺炎（OP）、过敏性肺炎、弥漫性肺泡损伤等，每一亚型的治疗和管理策略可能存在差异，需要进一步阐明。本文聚焦于DIILD中较为常见的OP亚类，定义药物诱导的OP（DIOP），对药物中最常见的抗肿瘤药物进行研究，了解抗肿瘤药物潜在的致OP机制，研究DIOP的诊断、鉴别诊断、治疗及预后，旨在更好地指导抗肿瘤药物诱导的OP相关诊疗。

Progress of Anticancer Drug-induced Organizing Pneumonia

Drug-induced lung injury has received more and more attention. The most common pattern is interstitial lung disease. The diagnosis, treatment and prognosis of drug-induced interstitial lung disease (DIILD) have been explored in many researches. However, there are still many subtypes of DIILD, including usual interstitial pneumonia, non-specific interstitial pneumonia, organizing pneumonia, hypersensitivity pneumonia and diffuse alveolar damage depending on the pathology. Each subtype may be different in treatment and management and further clarification is needed. This paper focused on the common subcategory of organizing pneumonia, naming it as drug-induced organizing pneumonia (DIOP) , explored the most common anticancer drugs, understood the potential mechanism of anticancer drugs to cause OP, and explored the diagnosis, differential diagnosis, treatment and prognosis of DIOP, so as to make a better guide on the diagnosis and treatment of organizing pneumonia induced by anticancer drugs.