| 治疗2型糖尿病新靶点药物研究新进展 |
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| 引用本文： | 张鹏翔,曾霖,孟璐,黄倩,王高祥,刘德亮.治疗2型糖尿病新靶点药物研究新进展[J].中国全科医学,2022,25(20):2551-2557. |
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| 作者姓名： | 张鹏翔 曾霖 孟璐 黄倩 王高祥 刘德亮 |
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| 作者单位： | 1518033 广东省深圳市，广州中医药大学第四临床医学院2518033 广东省深圳市，南京中医药大学附属深圳市中医院3518033 广东省深圳市中医院 |
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| 基金项目： | 国家自然科学基金青年科学基金项目(81704002) |
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| 摘 要： | 目前的2型糖尿病（T2DM）临床治疗药物种类繁多，噻唑烷二酮类、磺酰脲类、双胍类及胰岛素等传统降糖药物的降糖机制与安全性存在差异。近年来各种关于治疗T2DM的新靶点药物层出不穷，葡萄糖激酶激动剂、多重肠促胰岛素激动剂、胰高血糖素受体拮抗剂等新靶点药物通过不同机制逐渐满足临床个性化的治疗要求。本文对当前T2DM新靶点药物的研究进展进行综述，并分析各类新靶点药物临床研究的优、劣势，以期为T2DM临床治疗提供基础指导。
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| 关 键 词： | 糖尿病，2型 新靶点药物 药物疗法 综述 |
| 收稿时间： | 2022-01-08 |
New Research Progress of the Novel Target Drugs for the Treatment of Type 2 Diabetes Mellitus |
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| Pengxiang ZHANG,Lin ZENG,Lu MENG,Qian HUANG,Gaoxiang WANG,Deliang LIU.New Research Progress of the Novel Target Drugs for the Treatment of Type 2 Diabetes Mellitus[J].Chinese General Practice,2022,25(20):2551-2557. |
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| Authors: | Pengxiang ZHANG Lin ZENG Lu MENG Qian HUANG Gaoxiang WANG Deliang LIU |
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| Affiliation: | 1The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China2Shenzhen Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Shenzhen 518033, China3Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China |
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| Abstract: | At present, there are many types of drugs for clinical treatment of type 2 diabetes mellitus (T2DM) , there are differences in the hypoglycemic mechanisms and safety of traditional hypoglycemic drugs such as thiazolidinediones, sulfonylureas, biguanides, and insulin. In recent years, an assortment of new target drugs has emerged in an endless stream.New target drugs such as glucokinase activators, multi-site receptor agonists for GLP-1, GIP and glucagon, glucagon receptor inhibitors have gradually assembled the necessities of personalized clinical treatment through different mechanisms. This article reviews the current research progress of new target drugs for T2DM, and analyzes the advantages and disadvantages of clinical research of various new target drugs, in order to provide basic guidance for the clinical treatment of T2DM. |
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| Keywords: | Diabetes mellitus type 2 New target drugs Drug therapy Review |
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