| HIV/AIDS患者KIR3DS1基因与部分环境因素对其疾病进展的影响 |
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| 引用本文： | 朱 一,张学宁,吴建茹,张 钰,郭宏雄,傅更锋,徐金水,还锡萍,王 蓓.HIV/AIDS患者KIR3DS1基因与部分环境因素对其疾病进展的影响[J].南京医科大学学报,2013(2):191-194. |
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| 作者姓名： | 朱 一 张学宁 吴建茹 张 钰 郭宏雄 傅更锋 徐金水 还锡萍 王 蓓 |
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| 作者单位： | 东南大学公共卫生学院流行病与卫生统计学系,教育部环境医学工程重点实验室,江苏 南京 210009;东南大学公共卫生学院流行病与卫生统计学系,教育部环境医学工程重点实验室,江苏 南京 210009;东南大学公共卫生学院流行病与卫生统计学系,教育部环境医学工程重点实验室,江苏 南京 210009;东南大学公共卫生学院流行病与卫生统计学系,教育部环境医学工程重点实验室,江苏 南京 210009;江苏省疾病预防控制中心性病艾滋病防治所,江苏 南京 210024;江苏省疾病预防控制中心性病艾滋病防治所,江苏 南京 210024;江苏省疾病预防控制中心性病艾滋病防治所,江苏 南京 210024;江苏省疾病预防控制中心性病艾滋病防治所,江苏 南京 210024;东南大学公共卫生学院流行病与卫生统计学系,教育部环境医学工程重点实验室,江苏 南京 210009 |
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| 基金项目： | 国家自然科学基金资助(30872156) |
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| 摘 要： | 目的:探讨KIR3DS1基因及部分环境因素与人类免疫缺陷病毒(human immunodeficiency virus,HIV)-1感染者疾病进程的关系?方法:收集86例通过自愿咨询检测确认为HIV+患者的抗凝全血标本,采用聚合酶链反应-限制性片段长度多态性方法,检测其KIR3DS1基因,并进行问卷调查(调查内容包括人口学基本信息?临床表现?高危行为?是否接受抗病毒治疗等)收集部分环境因素信息?结果:Cox回归分析显示,风险比(RR)值为0.217(95%CI:0.098~0.480)?结论:抗病毒治疗可以延缓HIV-1感染者疾病进程,携带KIR3DS1基因可能延缓HIV-1感染者疾病进程?
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| 关 键 词： | 人类免疫缺陷病毒 杀伤细胞免疫球蛋白样受体 环境因素 |
| 收稿时间： | 2012/5/13 0:00:00 |
Correlation of KIR3DS1 alleles,environmental factors with the progression of HIV-1 infection in HIV/AIDS patients |
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| Zhu Yi,Zhang Xuening,Wu Jianru,Zhang Yu,Guo Hongxiong,Fu Gengfeng,Xu Jinshui,Huan Xiping and Wang Bei.Correlation of KIR3DS1 alleles,environmental factors with the progression of HIV-1 infection in HIV/AIDS patients[J].Acta Universitatis Medicinalis Nanjing,2013(2):191-194. |
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| Authors: | Zhu Yi Zhang Xuening Wu Jianru Zhang Yu Guo Hongxiong Fu Gengfeng Xu Jinshui Huan Xiping and Wang Bei |
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| Affiliation: | Department of Epidemiology and Biostatistics,School of Public Health,Southeast University,Nanjing 210009;Department of Epidemiology and Biostatistics,School of Public Health,Southeast University,Nanjing 210009;Department of Epidemiology and Biostatistics,School of Public Health,Southeast University,Nanjing 210009;Department of Epidemiology and Biostatistics,School of Public Health,Southeast University,Nanjing 210009;Institute of Veneral Disease and AIDS Control,Jiangsu Center for Disease Control and Prevention,Nanjing 210024;Institute of Veneral Disease and AIDS Control,Jiangsu Center for Disease Control and Prevention,Nanjing 210024;Institute of Veneral Disease and AIDS Control,Jiangsu Center for Disease Control and Prevention,Nanjing 210024;Institute of Veneral Disease and AIDS Control,Jiangsu Center for Disease Control and Prevention,Nanjing 210024;Department of Epidemiology and Biostatistics,School of Public Health,Southeast University,Nanjing 210009 |
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| Abstract: | Objective:To evaluate the correlation of KIR3DS1 alleles,environmental factors with the progression of HIV-1 infection in Chinese population. Methods:In total,86 cases of newly reported HIV/AIDS were recruited from people receiving voluntary counseling and testing(VCT). KIR3DS1 genes was assessed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Meanwhile,questionnaire survey was conducted to collect the environmental information. Results:Cox regression analysis showde that, compared with non-antivirus treatment group, the risk ratio (RR) of antivirus treatment was 0.217(95%CI =0.098~0.480). Conclusion:Antivirus treatment can delay the progression to AIDS,and KIR3DS1 gene may potentially be associated with slower progression to AIDS in Chinese population. |
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| Keywords: | HIV-l killer cell Ig-like receptors environmental factors |
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