| 乳腺癌组织HER-2/neu 和RECK蛋白的表达及其意义 |
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| 引用本文： | 沈 波,韦 达,徐新宇,陈 嘉,郑马庆.乳腺癌组织HER-2/neu 和RECK蛋白的表达及其意义[J].南京医科大学学报,2012(9):1237-1240. |
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| 作者姓名： | 沈 波 韦 达 徐新宇 陈 嘉 郑马庆 |
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| 作者单位： | 南京医科大学附属江苏省肿瘤医院肿瘤内科,江苏 南京 210009;南京医科大学附属江苏省肿瘤医院肿瘤内科,江苏 南京 210009;南京医科大学附属江苏省肿瘤医院肿瘤内科,江苏 南京 210009;南京医科大学附属江苏省肿瘤医院肿瘤内科,江苏 南京 210009;南京工业大学药学院,江苏 南京 211816 |
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| 基金项目： | 南京医科大学附属江苏省肿瘤医院科研基金(ZM200802) |
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| 摘 要： | 目的:探讨HER-2/neu和RECK蛋白在乳腺癌组织中的表达及其临床意义?方法:采用SP法,对76例乳腺癌组织标本及30例正常乳腺组织标本进行免疫组化检测,观察乳腺癌组织及正常乳腺组织中HER-2/neu和RECK蛋白表达情况,并比较不同TNM分期?病理分化程度乳腺癌组织HER-2/neu和RECK蛋白表达强度及阳性率差异,分析其两者之间的关系?结果:乳腺癌组织HER-2/neu表达强度及阳性率高于正常乳腺组织,RECK表达强度及阳性率低于正常乳腺组织,乳腺癌组织中HER-2/neu和RECK表达强度及阳性率同TNM分期及肿瘤组织分化具有相关性,乳腺癌组织HER-2/neu和RECK表达呈负相关?结论:乳腺癌组织中HER-2/neu过度表达?RECK表达减弱或缺失的现象,可能是乳腺癌发生?发展的生物学机制之一?
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| 关 键 词： | 乳腺癌 HER-2/neu RECK 肿瘤分期 肿瘤分化 |
| 收稿时间： | 2012/5/10 0:00:00 |
Expression and clinical significance of HER-2/neu and RECK in breast carcinoma tissue |
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| SHEN Bo,WEI D,XU Xin-yu,CHEN Jia and ZHENG Ma-qing.Expression and clinical significance of HER-2/neu and RECK in breast carcinoma tissue[J].Acta Universitatis Medicinalis Nanjing,2012(9):1237-1240. |
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| Authors: | SHEN Bo WEI D XU Xin-yu CHEN Jia and ZHENG Ma-qing |
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| Affiliation: | Department of Medical Oncology,the Affiliated Jiangsu Cancer Hospital of NJMU,Nanjing 210009;Department of Medical Oncology,the Affiliated Jiangsu Cancer Hospital of NJMU,Nanjing 210009;Department of Medical Oncology,the Affiliated Jiangsu Cancer Hospital of NJMU,Nanjing 210009;Department of Medical Oncology,the Affiliated Jiangsu Cancer Hospital of NJMU,Nanjing 210009;College of Pharmacy,Nanjing University of Technology,Nanjing 211816,China |
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| Abstract: | Objective:To investigate the expression and clinical significance of HER-2/neu and RECK in breast carcinoma tissue. Methods:A total of 76 cases of breast carcinoma tissue and 30 cases of normal breast tissue were selected and stained with SP immunohistochemical method to detect the expression of HER-2/neu and RECK,positive rate and intensity were compared among cases with different TNM stage and differentiation of breast carcinoma,correlation between HER-2/neu and RECK was analyzed in breast carcinoma tissue. Results:Positive rate and intensity of HER-2/neu were higher and RECK were lower in breast carcinoma tissue than those in normal breast tissue,which were correlative with TNM stage and differentiation of breast carcinoma,the expression of HER-2/neu was negatively correlated with RECK in breast carcinoma tissue. Conclusion:HER-2/neu was over expressed while RECK was not expressed or at a low level in breast carcinoma tissue,these might be a biological mechanism for the occurrence and progression of breast carcinoma. |
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| Keywords: | breast carcinoma HER-2/neu RECK tumor differentiation tumor stage |
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