抗抑郁干预对围放疗期癌症患者情绪状况的影响

目的 探讨抗抑郁干预对围放疗期癌症患者情绪状况的影响.方法 对62名放疗患者按接受放疗的时间顺序分为药物干预组(接受抗抑郁药物治疗6周)和对照组,采用汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)测查.结果 HAMA、HAMD测杳结果显示,抗抑郁药物干预组与对照组比较,放疗前焦虑、抑郁差异无显著性;放疗期间的焦虑干预组(6.41±2.30)分,对照组(9.29±5.62)分]、抑郁干预组(8.80±3.05)分,对照组(12.22±8.32)分]差异有显著性(P＜0.05);放疗结束后2周的焦虑干预组(4.90±1.71)分,对照组(12.32±7.24)分]、抑郁干预组(6.83±2.47)分,对照组(16.09±8.61)分]差异有显著性(P＜0.01).结论 应重视癌症放疗患者不同时期的心理状况,并应用抗抑郁药物,缓解其焦虑、抑郁情绪.

Effect of antidepressant intervention on mood state of at or around the time of radiation therapy

Objective To explore the effect of antidepressant intervention on mood state of at or around the time of radiation therapy. Methods 62 hospitalized patients with cancer receiving radiotherapy were divided into two groups by the order of the time when they accept the radiotherapy which called intervention group ( antidepressant fluoxetine group) and control group. And the two groups patients filled out Hamilton Anxiety Scale( HAMA )and Hamilton Depression Scale (HAMD) at or around the time of radiation therapy to investigate the effects of fluoxetine on anxiety and depression. Results The scores of HAMA and HAMD showed that there was no differences between the intervention group and the control group before the radiotherapy. There was significant difference during the radiotherapy ( 6.41 ± 2.30 ) vs ( 9.29 ± 5.62 ); ( 8.80 ± 3. 048 ) vs ( 12.22 ± 8.32 ) and two weeks after the end of the radiotherapy ( 4.90 ± 1.71 ) vs ( 12.32 ± 7.24 ); ( 6.83 ± 2.47 ) vs ( 16.09 ± 8.61 ) between antidepressant fluoxetine group and control group(P ＜ 0.05 ). Conclusion More attention should be paid to mental health and antidepressant can alleviate anxiety and depression of the cancer patients'at or around the time of radiotherapy.