安徽省亳州市11名未成年人新型冠状病毒肺炎的感染特征分析

  目的  研究安徽省亳州市新型冠状病毒肺炎(COVID-19)0~17岁未成年人患者的流行病学特征及临床特点。  方法  本项回顾性研究纳入了11例安徽省亳州市2020年1月24日—2月12日收治的所有未成年人确诊病例，并进行流行病学、临床、放射学特征及实验室数据分析。  结果  11名COVID-19未成年人患者年龄中位数为10.54(7.50, 13.00)岁，其中男6例，女5例。所有患者均经RT-PCR检测到新型冠状病毒(SARS-Cov-2)，均至少有1名家人感染了SARS-Cov-2。4例(36.3%)患者出现发热，8例(72.7%)患者出现轻度上呼吸道感染症状，包括2例(18.2%)咳嗽，1例(9.1%)肌肉疼痛，2例(18.2%)咽喉痛，4例(36.4%)出现鼻塞、流涕，1例(9.1%)在确诊COVID-19前1~2 d表现出明显的胃肠道症状等临床表现。8例患者(72.7%)出现淋巴细胞计数减少，9例(81.8%)患者的C反应蛋白升高，3例(27.2%)患者的ALT和AST升高，4例患者(36.4%)的白细胞计数正常。影像学检查显示，3例(27.2%)患者出现双侧肺炎，5例(45.5%)患者表现为多发性斑点和磨玻璃样特征。  结论  与成人相比，目前未成年人病例不多，相关研究还不充足，以上资料为本次疫情的有效防控和精准救治提供了宝贵的指导意见。 

Infection characteristics of 11 juvenile cases of COVID-19 in BoZhou City,Anhui Province

  Objective  To study the epidemiological and clinical characteristics of juvenile patients with coronavirus disease 2019 (COVID-19) in BoZhou City, Anhui Province.  Methods  We conducted a retrospective study focusing on 11 juvenile patients diagnosed with COVID-19 in BoZhou City, Anhui Province from 24 January 2020 to 12 February 2020. Epidemiological, demographic, clinical, laboratory, radiological and treatment data were collected and analysed.  Results  Amongst the hospitalised juvenile patients with COVID-19, the median age was 10.54(7.5, 13.0) years, and 6(54.5%) were male. All 11 patients were detected by real-time RT-PCR, and at least 1 family members were infected with COVID-19. Patients had clinical manifestations of fever 4(36.3)% patients], mild upper respiratory tract symptoms 8(72.7%) patients], cough 2(18.2%) patients], muscle ache 1(9.1%) patients], sore throat 2(18.2%) patients] and nasal congestion 4(36.4%) patients]. One patient (9.1%) showed significant gastrointestinal symptoms and other clinical manifestations 1-2 days before the diagnosis of COVID-19. Eight patients (72.7%) had decreased lymphocyte counts, 9(81.8%) had elevated c-reactive protein levels, 3(27.2%) had elevated ALT and AST, and 4(36.4%) had normal white blood cell counts. According to imaging examination, 3(27.2%) patients showed bilateral pneumonia, and 5(45.5%) patients showed multiple mottling and ground-glass opacity.  Conclusion  Compared with adults, there are not many cases of juvenile patients, and relevant studies are insufficient. The above information provides valuable guidance for the effective management and accurate treatment of this disease.