急性脑梗死患者血清学指标与神经功能缺损和脑梗死体积及颈动脉斑块性质的相关性研究

目的 探讨急性脑梗死(ACI)患者超敏C-反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)及脂蛋白相关磷脂酶-A2(Lp-PLA2)与神经功能缺损、脑梗死体积及颈动脉斑块性质的相关性。 方法 选择2017年6月—2020年2月在杭州师范大学附属医院收治的ACI患者120例(ACI组),另选取同期体检健康人群60例(健康对照组)。比较不同分组hs-CRP、MMP-9及Lp-PLA2水平变化,Spearman法分析相关性。 结果 ACI组hs-CRP、MMP-9及Lp-PLA2水平明显高于健康对照组(t=20.364、22.115、14.163,均P<0.05);轻、中、重度神经功能缺损组hs-CRP、MMP-9及Lp-PLA2水平依次升高,差异显著(F=171.283、82.137、278.610,均P<0.05);小、中、重梗死灶组hs-CRP、MMP-9及Lp-PLA2水平依次升高,差异显著(F=100.672、59.707、134.199,均P<0.05);无、稳定、不稳定斑块组hs-CRP、MMP-9及Lp-PLA2水平依次升高,差异显著(F=50.120、34.056、67.255,均P<0.05)。ACI患者MMP-9、hs-CRP及Lp-PLA2水平与神经功能缺损、脑梗死体积、颈动脉斑块性质均呈正相关(均P<0.05)。 结论 斑块性质越不稳定、脑梗死体积越大、神经功能缺损程度越高,ACI患者血清hs-CRP、MMP-9及Lp-PLA2水平越高。 

Correlation of hs-C R P,MMP-9 and Lp-PLA2 with neurological deficit,cerebral infarction volume and carotid plaque properties in patients with acute cerebral infarction

Objective To investigate the correlation of plasma High-sensitivity C-reactive protein(hs-CRP), matrix metalloproteinase-9(MMP-9) and lipoprotein-related phospholipase A2(Lp-PLA2) levels with neurological impairment, cerebral infarction volume and carotid artery plaque stability in patients with acute cerebral infarction(ACI). Methods A total of 120 ACI in patients(ACI group) who were admitted in the Affiliated Hospital of Hangzhou Normal University from June 2017 to February 2020 were selected, and 60 healthy people for physical examination during the same period were selected as health control group. The levels of hs-CRP, MMP-9 and Lp-PLA2 in different groups were compared, and the Spearman Method was used to analyze the correlation. Results The levels of hs-CRP, MMP-9 and Lp-PLA2 in the ACI group were significantly higher than those in the healthy control group(t=20.364, 22.115, 14.163, all P<0.05); the levels of hs-CRP, MMP-9 and Lp-PLA2 in the mild, moderate, and severe neurological deficit groups increased sequentially, with significant differences(F=171.283, 82.137, 278.610, all P<0.05); the levels of hs-CRP, MMP-9 and Lp-PLA2 in the small, moderate, and severe infarct focus group increased sequentially, with significant differences(F=100.672, 59.707, 134.199, all P<0.05); the levels of hs-CRP, MMP-9 and Lp-PLA2 in the non-, stable, and unstable plaque groups increased sequentially, with significant differences(F=50.120, 34.056, 67.255, all P<0.05). The levels of MMP-9, hs-CRP and Lp-PLA2 in ACI patients were positively correlated with neurological deficits, cerebral infarction volume, and carotid plaque Carotid stability(all P<0.05). Conclusion The more unstable the plaque nature, the larger the cerebral infarction volume and the higher the neurological function defect degree were, the higher the serum HS-CRP, MMP-9 and LP-PLA2 levels were.