缺血性脑卒中患者血尿酸水平与脑动脉狭窄的相关性研究

目的：探讨缺血性脑卒中患者血尿酸（SUA）水平与脑动脉狭窄之间的关系。方法从收治的缺血性脑卒中患者中，随机选择经脑血管造影术确诊有脑动脉狭窄的患者186例、无狭窄患者42例。根据造影结果，将脑动脉狭窄分为轻度狭窄组74例，中度狭窄组66例和重度狭窄组46例。单支血管狭窄103例，多支血管狭窄83例。比较不同组别间SUA水平的差异以及SUA与脑动脉狭窄程度之间的关系。结果无狭窄患者SUA水平明显低于有狭窄患者（P＜0．05），轻度狭窄组SUA水平明显低于中度狭窄组（P＜0．05），中度狭窄组SUA水平低于重度狭窄组（P＜0．05）。脑动脉狭窄与血尿酸水平呈正相关（r＝0．413，P＜0．05），Logistic回归分析显示SUA并不是脑动脉狭窄的独立危险因素（P＝0．213）。结论 SUA水平与脑动脉狭窄呈正相关，但不是脑动脉狭窄的独立危险因素。

Relationship between serum uric acid and cerebral artery stenosis in patients with ischemic stroke

Objective To study the relationship between serum uric acid（SUA）level and cerebral artery stenosis in patients with ischemic stroke.Methods Patients with ischemic stroke were examined with subtraction and diagnosed as with（186）and without cerebral artery stenosis（42）.Patients with stenosis were further grouped as slight（74）,moderate（66）,and severe stenosis（46）.There were 103 pa-tients with single stenosis and 83 patients with dual cerebral artery stenosis.The serum uric acid levels of the groups patients were researched. Results The level of SUA was significantly lower in patients without than in patients with cerebal artery stenosis（P〈0.01）;SUA was sig-nificantly lower in patient with mild stenosis than in patients with moderate stenosis（P〈0.05）;significantly lower in patients with moderate stenosis than in patients with severe stenosis（P〈0.05）.Spearman rank correlation analysis showed that SUA level and the degree of cerebral artery stenosis was positively correlated（r=0.413,P〈0.01）.Logistic regression analysis showed that SUA level was not an independent risk factor of cerebral artery stenosis（P=0.213）.Conclusion There is correlation between SUA level and the severity of the cerebral artery ste-nosis,but SUA level is not an independent risk factor for cerebral artery stenosis.