环磷酰胺联合激素治疗狼疮性肾炎的临床观察

目的观察环磷酰胺（CTX）联合激素治疗狼疮性肾炎的疗效。方法将49例狼疮性肾炎（LN）患者随机分为两组。对照组用激素治疗；治疗组用环磷酰胺联合激素间歇冲击治疗，即CTX0．4—0．6g／d静脉滴注，连用2d，每2周1次。结果治疗3个月后，治疗组总有效率为89．3％，对照组为66．7％．治疗组24h尿蛋白、血肌酐、血沉、尿红细胞及狼疮活动性分数低于对照组（P〈0．05），补体C3高于对照组（P〈0．05）。结论环磷酰胺联合激素治疗狼疮性肾炎可显著增加疗效，使病情缓解，不易复发，且不良反应较少。

Clinical Observation of Cyclophosphamide and Corticosteroid Treatment for Lupus Nephritis

Objective To study the effect of impulsion treating lupus nephritis （LN） with pulse cyclophosphamide（CTX） and corticosteroid. Methods All the patients were divided into two groups randomly. Only Corticosteroid in the control group, Corticosteroid and CTX were intravenously with 0.4 - 0.6g/d for two days and once for two weeks in treated group. Results The total effective rate the in treated group was 89.3% and in the control group was 66.7%. Twenty-four hours urinary protein and urinary red blood cell,Scr, complement C3, ESR, the Systemic Lupus Erythematosus Activity Index （ SLEDAI ） all significanty improved in experiment group（ P 〈0.05 ） ,the side effects were less common in experiment group than in control group. Conclusion The combination pulse therapy with CTX and corticosteroid is safe and effective on the treatment of LN.