| CD44v6和MMP-9及VEGF在胃癌组织中的表达及临床意义 |
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| 引用本文： | 程鑫,张仕状,王滨,董鹏.CD44v6和MMP-9及VEGF在胃癌组织中的表达及临床意义[J].潍坊医学院学报,2008,30(4):319-321. |
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| 作者姓名： | 程鑫 张仕状 王滨 董鹏 |
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| 作者单位： | 潍坊医学院医学影像学系,山东,潍坊,261042 |
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| 摘 要： | 目的探讨胃癌组织中CD44v6，MMP-9和VEGF的表达情况及其临床意义。方法采用免疫组化方法测定60例胃癌组织CD44v6，MMP-9，VEGF表达情况，并结合患者的临床病理资料进行分析。结果胃癌组织中CD44v6，MMP-9，VEGF的阳性表达率分别为60％，53．8％和75％，CD44v6，MMP-9，VEGF的表达与肿瘤的TNM分期、浸润深度、淋巴结转移有关（P〈0．05）。结论CD44v6，MMP-9，VEGF的表达与胃癌的浸润转移密切相关。
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| 关 键 词： | 胃肿瘤 CD44V6 MMP-9 VEGF |
Expression and Clinical Significance of CD44v6,MMP-9 and VEGF in Gastric Carcinoma |
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| CHENG Xin,ZHANG Shi-zhuang,WANG Bin,DONG Peng.Expression and Clinical Significance of CD44v6,MMP-9 and VEGF in Gastric Carcinoma[J].Journal of Weifang Medical College,2008,30(4):319-321. |
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| Authors: | CHENG Xin ZHANG Shi-zhuang WANG Bin DONG Peng |
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| Affiliation: | ( Department of Medical Imaging, We ifang Medical College, Weifang 261042, China ) |
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| Abstract: | Objective To investigate the expression of CD44V6, MMP-9 and VEGF in gastric carcinoma. Methods Sixty cases of gastric carcinoma were detected the expression of CD44V6, MMP-9 and VEGF using immunohistochemistry. Results In 60 cases, CD44v6,MMP-9 and VEGF positive rate were 60% ,53.8% and 75% ,respectively. The expression of CD44v6,MMP-9 and VEGF was significantly related with TNM staging, tumor invasion and lymph node metastasis （ P 〈 0.05 ）. Conclusion The expression of CD44v6, MMP-9 and VEGF are closely correlated with the invasion and metastasis of gastric carcinoma. |
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| Keywords: | CD44v6 MMP-9 VEGF |
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