| 慢性肾功能衰竭血液透析病人血浆水溶性脂质过氧化物的改变及意义 |
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| 引用本文： | 蔡扬,陈一玲,古英明.慢性肾功能衰竭血液透析病人血浆水溶性脂质过氧化物的改变及意义[J].广州医学院学报,1997(5). |
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| 作者姓名： | 蔡扬 陈一玲 古英明 |
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| 作者单位： | 广州医学院第二附属医院血液净化中心(蔡扬，古英明)，广东医药学院(陈一玲) |
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| 摘 要： | 自由基与各种肾病及其终未期的发生和发展有密切关系。本文对31例尿毒症患者的血浆水溶性脂质过氧化物（WaterSolubleFlurescentSubstancer．WSFS）用荧光光谱法进行测定，并与正常人及尿毒症病人血液透析前后的WSFS变化对比分析，结果显示尿毒症病人的WSFS明显升高，提示WSFS检测可以从一个侧面了解患者体内氧化应激增强状态及对病人的肾功能和心脑血管并发症发展趋势的判断具有一定意义。此外由于血液透析不能明显降低患者血浆WSFS含量，提示对尿毒症病人进行血液透析改善内环境同时，还应积极给予抗氧化物及抗氧化物酶的治疗具有重要意义。
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| 关 键 词： | 自由基 脂质过氧化物 血液透析 终末期肾病 |
The Change Significance of WSFS in CRF Patient's with Hemodialysis |
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| Cai Yang, Gu Ying ming,.The Change Significance of WSFS in CRF Patient''''s with Hemodialysis[J].Academic Journal of Guangzhou Medical College,1997(5). |
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| Authors: | Cai Yang Gu Ying ming |
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| Abstract: | The water soluble fluorescent substances 9WSFS) value in plasma of 31 cases of chronic renalfailure (CRF) was determined, before and after the patient's blood had been dialysed before andafter the dialysis, the WSFS level by 5 - fold compared to the level in the control persons, Therewas no signific and difference of WSFS between undialysed CRF plasma and dialysed CRF plasma.These results indicated the free radical in CRF patients was increased and it enhanced lipidperoxidation. Because WSFS were m binding compounds between the degraded lipids and serumproteins, They were big molecules, so could not be cleared away easily by blood dialysis. |
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| Keywords: | Free radical water soluble fluorescent substances hemodialysis uremia renal failure |
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