| 滂胺天蓝与阿米卡星相互作用的共振瑞利散射光谱及其应用 |
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| 引用本文： | 韩文莉,曲斐,陆巍,尚京川.滂胺天蓝与阿米卡星相互作用的共振瑞利散射光谱及其应用[J].重庆医科大学学报,2011,36(2). |
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| 作者姓名： | 韩文莉 曲斐 陆巍 尚京川 |
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| 作者单位： | 重庆医科大学药学院药物分析教研室,重庆,400016 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的:采用共振瑞利散射法(Resonance Rayleigh scattering,RRS)测定不同制剂中阿米卡星(Amikacin,AMK)的含量.方法:考察RRS增强的机理、反应条件对RRS强度的影响以及AMK浓度与RRS强度的关系.结果:在pH3.0的Britton-Robinson缓冲液中,滂胺天蓝(Pontamine sky blue,PSB)与AMK在静电引力及疏水性作用结合成组成比为2∶1的离子缔合物.AMK的浓度在0.01～1.7mg/L范围内与RRS强度成正比,检出限(3σ)为3.0μg/L.结论:该法简便快速、结果准确可靠,可用于不同制剂中AMK的含量测定.
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| 关 键 词： | 共振瑞利散射 阿米卡星 滂胺天蓝 |
The resonance Rayleigh scattering spectra of the interaction between amikacin and pontamine sky blue and its application |
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| HAN Wen-li,et al.The resonance Rayleigh scattering spectra of the interaction between amikacin and pontamine sky blue and its application[J].Journal of Chongqing Medical University,2011,36(2). |
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| Authors: | HAN Wen-li |
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| Affiliation: | HAN Wen-li,et al(Department of Pharmaceutical Analysis,College of Pharmaceutical,Chongqing Medical University) |
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| Abstract: | Objective:To determine simply and rapidly amikacin(AMK) in different pharmaceutical formulations with resonance Rayleigh scattering(RRS) method.Methods:The mechanism of generating greatly enhanced RRS signals,the effects of the interacting conditions on the enhanced intensity of RRS,and the relationship between the enhanced RRS intensity and the concentration of AMK were investigated.Results:In a Britton-Robinson buffer solution(pH3.0),AMK interacted with pontamine sky blue(PSB) to form an ion-association c... |
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| Keywords: | resonance Rayleigh scattering amikacin pontamine sky blue |
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