| 川芎嗪抑制IL-8诱导人卵巢癌SKOV3细胞的迁移作用 |
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| 引用本文： | 殷娟,于超,杨竹.川芎嗪抑制IL-8诱导人卵巢癌SKOV3细胞的迁移作用[J].重庆医科大学学报,2011,36(4):401-403. |
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| 作者姓名： | 殷娟 于超 杨竹 |
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| 作者单位： | 殷娟,杨竹(重庆医科大学附属第二医院妇产科,重庆,400010);于超(重庆医科大学生命科学研究院,重庆,400016) |
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| 基金项目： | 重庆市科委自然科学基金资助项目，重庆医科大学重点基金资助项目 |
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| 摘 要： | 目的:观察外源白介素-8(Interleukin-8,IL-8)对人卵巢癌SKOV3细胞迁移的影响,及川芎嗪(Tetramethylpyrazine,TMP)对它的干预作用,初步研究其可能机制.方法:TMP处理SKOV3细胞后,MTF法确定药物浓度;细胞划痕实验观察外源IL-8对SKOV3细胞迁移能力的影响,采用Tra...
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| 关 键 词： | 川芎嗪 卵巢癌 IL-8 细胞迁移 |
Mechanisms of TMP inhibiting cell migration in SKOV3 cells induced by extraneous IL-8 |
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| YIN Juan,et al.Mechanisms of TMP inhibiting cell migration in SKOV3 cells induced by extraneous IL-8[J].Journal of Chongqing Medical University,2011,36(4):401-403. |
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| Authors: | YIN Juan |
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| Affiliation: | YIN Juan,et al (Department of Obstetries and Gynecology,the Second Affiliated Hospital,Chongqing Medical University) |
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| Abstract: | Objective:To investigate whether tetramethylpyrazine(TMP)has the activity of inhibition on cell migration induced by extraneous Interleukin-8(IL-8) in SKOV3 cell,and to understand its probable mechanisms.Methods:MTT was used to determine the concentrations of TMP.The wound healing assay and transwell assay were used to study the cell migration.The protein expression levels of E-cadherin and matrix metalloproteinase 9(MMP-9) were detected by Western blot.Results:IL-8(100 ng/ml)increased the ability of cell m... |
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| Keywords: | IL-8 |
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