| 免疫因素与男性不育的相关性 |
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| 引用本文： | 杨加周,赵豫凤,景彩霞,艾庆燕,苗乃周.免疫因素与男性不育的相关性[J].第四军医大学学报,2004,25(18):1701-1703. |
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| 作者姓名： | 杨加周 赵豫凤 景彩霞 艾庆燕 苗乃周 |
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| 作者单位： | 延安大学医学报组织学与胚胎学教研室;延安大学医学报寄生虫学教研室,陕西,延安,716000 |
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| 摘 要： | 目的: 观察不育男性血清抗精子抗体(AsAb),抗心磷脂抗体(ACA),抗弓形虫抗体与精液各指标之间的关系,揭示免疫因素与不育症的相关性及致病机制. 方法: 用ELISA(nzyme-linked immunosorbent assay)法测定286例男性不育患者及198例正常生育者血清的AsAb, ACA,抗弓形虫抗体并常规检测精液的各项指标. 结果: 不育者血清中的AsAb, ACA, 抗弓形虫抗体阳性率(29.4％, 18.2％, 17.1％)明显高于正常生育组(9.0％, 7.0％, 9.0％),P＜0.01;不育患者血清AsAb水平变化能导致精子的活动力明显下降,呈显著性正相关, P＜0.01. 结论: AsAb与男性不育有密切关系,可引起精子活率、活力明显下降,但对精子密度及液化无明显影响.
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| 关 键 词： | 不育 男(雄)性 抗精子抗体 抗体 抗心脂 弓形虫病 酶联免疫吸附测定 精液 |
| 文章编号： | 1000-2790(2004)18-1701-03 |
| 修稿时间： | 2004年7月6日 |
Correlation between immune factor and male infertility |
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| YANG Jia-Zhou ,ZHAO Yu-Feng ,JING Cai-Xia ,AI Qing-Yan ,MIAO Nai-Zhou.Correlation between immune factor and male infertility[J].Journal of the Fourth Military Medical University,2004,25(18):1701-1703. |
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| Authors: | YANG Jia-Zhou ZHAO Yu-Feng JING Cai-Xia AI Qing-Yan MIAO Nai-Zhou |
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| Affiliation: | YANG Jia-Zhou 1,ZHAO Yu-Feng 1,JING Cai-Xia 2,AI Qing-Yan 1,MIAO Nai-Zhou 1 1Department of Histology & Embryology,2Department of Parasitology,Medical College of Yan'an University,Yan'an 716000,China |
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| Abstract: | AIM: To examine the relationship between antisperm antibody (AsAb), anticardiolipin antibody (ACA) and anti-toxoplasma antibody in the sera of inferlile of males, and other indexes of semen and to study the correlation and mechanism of AsAb, ACA, anti-toxoplasma antibody and infertility. METHODS: AsAb, ACA and anti-toxoplasma antibody in sera from 286 cases of male infertile patients and 198 normal persons were measured with enzyme-linked immunosorbent assay (ELISA) and other indexes of semen were also detected. RESULTS: The positive rate of AsAb (29.4%), ACA (18.2%) and anti-toxoplasma antibody (17.1%) in the sera of infertile patients was significantly higher than that of normal controls (9.0%, 7.0% and 9.0%, respectively, P<0.01). The change of AsAb level could cause a remarkable decrease of sperm activity and a significant positive correlation was found (P<0.01). CONCLUSION: AsAb is closely related to male infertility and may lead to a remarkable decrease of sperm activity, but it does not significantly affect sperm density and liquidization. |
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| Keywords: | infertility male antisperm antibody antibodies anticardiolipin toxoplasmosis enzyme-linked immunosorbent assay semen |
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