隐血珠在上消化道癌初筛普查中实用价值研究

目的通过对隐血珠初筛人群及癌患者5年、10年随访,进一步证实隐血珠对上消化道癌初筛普查的实用价值。方法空腹时吞入隐血珠,3～5分钟拉出,观察珠内试纸的变化,黄色为阴性(-),浅蓝色为(+),蓝色为(++),深蓝色为(+++),5年、10年后对隐血珠初筛人群及癌患者通过三级防癌网络进行全员随访。结果初筛普查31927人,阳性组3347人做胃镜,经病理确诊为癌患者125人,癌检出率3.74％;阴性组645人做胃镜,确诊癌患者9人,癌检出率1.4％,两组中早期癌患者共78人,占62.4％,性别、年龄、隐血珠反应均是影响癌检出率的因素,经5年及10年两次全员随访资料统计,隐血珠初筛阳性组癌发率均明显高于阴性组,癌患者5年生存率67.2％,10年生存率为55.2％,性别、年龄、隐血珠反应也是影响筛查人群上消化道癌发生率的因素。结论隐血珠在上消化道癌初筛普查中有肯定的实用价值,值得推广。

Investigation of the Utility Value in Hemoccult Test Bead for Screening of Upper Digestive Tract

Objective To investigate the utility value of hemoccult test bead in screening upper digestive tract cancer. Methods Bead, Swallowed and retained in the stomach for 3 to 5 minutes, was able to sort out the individv(?) its coloration: yellow ( - ) , light blue ( + ), blue ( + + ) , and dark blue ( + + + ) .The screening crowd and cancer patients were folloned up after 5 years and 10 years through the three - tier cancer prevention net.Results In the 31927 normal subjects screened 3347 subjects were positive and examined by gastroscope, and 125 subjects were found to be cancer with pathology, the relevance ratio is 3.74 per.645 subjects in negative group were examined by gastroscope, and 9 subjects were found to be cancer, the relevance ratio is 3.74 per.The patients with early cancer among the two groups were totaled to be 78 subjects, per centum was 62.4, In the 5 and 10 years' follow- up, Cancer occur ratio have distinct different between the positive and negative groups.The 5 and 10 year survive rate is 67.2% and 55.2% .Sex, age and reaction level of hemoccult were three important factors which influence the cancer relevance ratio and occur rate. Conclusions Hemoccult test bead has definite utility value in screening upper digestive tract cancer, and has value to be recommended widely.