青刺果多糖对糖尿病小鼠心肌组织病理变化的影响

目的观察青刺果多糖对四氧嘧啶诱导的糖尿病小鼠心肌组织病变的影响。方法腹腔一次性注射四氧嘧啶复制模型。造模成功后，将实验动物分为模型组和青刺果多糖治疗组（300mg/kg），另设正常组。实验小鼠分别于给药2周末和4周末测定空腹12h血糖，然后随机处死，取心固定于4％多聚甲醛溶液中，制作病理切片，经苏木素-伊红（HE）染色后光镜下观察。结果青刺果多糖治疗组与模型组相比，血糖显著降低，差异有统计学意义（P〈0．05）；光镜下，模型组小鼠心肌纤维纵横纹模糊，心肌细胞有颗粒变性、脂肪变性，部分区域心肌纤维互相融合，可见呈灶性分布的嗜酸性变的心肌纤维，并伴有坏死、纵横纹消失、间质内纤维母细胞增生，严重者可见心肌纤维化形成的瘢痕。经青刺果多糖治疗后，心肌纤维纵横纹清晰，排列整齐，呈性分布的嗜酸性变的心肌纤维减少，可见少量的纤维细胞增生。结论青刺果多糖对糖尿病小鼠心肌具有保护作用。

Effect of Polysaccharide from Prinsepia Utilis Royle on the Pathological Change of Cardiac Muscle Tissue in Diabetic Mice

Objective To investigate the effects of polysaccharide from prinsepia utilis royle on the myocardial pathology in diabetic mice induced by alloxan.Methods Alloxan was administered intraperitoneally to establish diabetic model in mice.After the model developed,experimental animals were divided into the model group,the group of treatment with polysaccharide prinsepia utilis royle(300 mg/kg)and the control group.Two weeks and four weeks later,level of blood glucosemices after fasting12 hours was detected after...