| Effect of Salvia Miltiorrhiza on Left Ventricular Hypertrophy and Cardiac Aldosterone in Spontaneously Hypertensive Rats |
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| 作者姓名： | 韩少杰 郑智 任大宏 |
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| 作者单位： | DepartmentofEmergencyMedicine，DepartmentofEmergencyMedicine，DepartmentofPathology TongjiHospital，TongjiMedicalCollege，HuazhongUniversityofScienceandTechnology，Wuhan430030，TongjiHospital，TongjiMedicalCollege，HuazhongUniversityofScienceandTechnology，Wuhan430030，SchoolofBasicMedicalSciences，TongjiMedicalCollege，HuazhongUniversityofScienceandTechnology，Wuhan430030 |
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| 基金项目： | Thisprojectwassupported by a grant from Natural Sci-ences Foundation of Hubei Province(No. 2 0 0 0 J0 6 4 ) |
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| 摘 要： | Left ventricular hypertrophy ( LVH) is themostpopular cardiac complication of hypertension,as well as an important and independent predictorof cardiac morbidity and mortality. Cardiac fibro-sis,the remodeling of extracellular matrix withinmyocardium during the development of pressureoverload,is the pathological basis of ventriculardysfunction and arrhythmia1] . Previous studieshave shown that a functioning system involvingboth circulating and local aldosterone ( Aldo) con-tributes to the adv…
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| 关 键 词： | 丹参 高血压 左心室肥大 |
| 收稿时间： | 20 September 2001 |
Effect of salvia miltiorrhiza on left ventricular hypertrophy and cardiac aldosterone in spontaneously hypertensive rats |
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| Shaojie Han,Zhi Zheng,Dahong Ren.Effect of Salvia Miltiorrhiza on Left Ventricular Hypertrophy and Cardiac Aldosterone in Spontaneously Hypertensive Rats[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2002,22(4):302-304. |
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| Authors: | Shaojie Han Zhi Zheng Dahong Ren |
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| Affiliation: | 1. Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wruhan,430030
2. Department of Pathology, School of Basic Medical Sciences, Tongji Medical College,Huazhong University of Science and Technology, Wuhan,430030 |
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| Abstract: | Chronic treatment with Salvia Miltiorrhiza preventing left ventricular hypertrophy (L VH) and its possible mechanism- inhibiting the action of cardiac aldosterone in spontaneously hypertensive rats (SHR) were investigated.Normotensive Wistar- kyoto (WKY ) rats and SHRs were used.Part of SHRs was treated with Salvia Miltiorrhiza for 12 weeks.Systolic blood pres- sure (SBP) and left ventricular mass index were measured.Sections of heart tissue were stained with HE method and Van Gieson method.Collagen volume fraction was determined in the leftven- tricle by automatically quantitative m orphometry.Cardiac aldosterone concentration was measured by radioimm unoassay.The results indicated thatcom pared with WKY rats,SHRs exhibited high- er SBP,left ventricular collagen volume fraction,and aldosterone concentration (all P<0 .0 5 ) . After the treatm ent with Salvia Miltiorrhiza,SBP,left ventricular collagen volum e fraction,and aldosterone concentration in SHR were decreased as compared with control group (P<0 .0 5 ) ex- cept SBP.It was concluded thatchronic treatment with Salvia Miltiorrhiza could preventleftven- tricular hypertrophy in SHR,significantly inhibit collagen compositions in left ventricle.The m echanism was probably related with the inhibition of the cardiac aldosterone action. |
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| Keywords: | Salvia Miltiorrhiza spontaneously hypertensive rats leftventricular hypertrophy al- dosterone |
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