慢性复发性丙型肝炎的优化治疗疗效分析与比较

目的：研究探讨慢性复发性丙型肝炎的优化治疗方案及其最新研究。方法选择2008年5月至2012年5月至该院传染病科就诊的慢性复发性丙肝的患者50例，分为两组，每组25例，甲组采用标准治疗延长疗程方案，乙组采用标准治疗加大剂量方案，通过观察两组的持续病毒学应答(SVR)来比较两组治疗方法的效果，并观察6个月后的复发情况。结果甲组获得32%的 SVR 率，乙组获得23%的 SVR 率；6个月后甲组的复发率为38%，乙组为43%，差异均有统计学意义(P <0.05)。结论甲组的标准治疗延长疗程方案的临床 SVR 率高于乙组。

Analysis and comparison in optimized treatment of chronic recurrent hepatitis C

Objective To optimize the treatment of chronic hepatitis C recurrence.Methods During May 2008 to May 2012, 50 patients with chronic recurrent hepatitis C were chosen in the infectious department of our hospital.They were divided into two groups with 25 cases in each group.Group A was treated by standard extended treatment scheme,while Group B was treated by standard large dose scheme.The effect was estimated by the observation of sustained virologic response in the two groups (sus-tained virologic response,SVR).Results 32% SVR rate was found in group A and 23% SVR rate was found in Group B.38% re-currence rate appeared in group A after six months and 43% recurrence rate occurred in group B,there were significant difference between two groups(P <0.05).Conclusion The standard extended treatment schemes of pegylated interferon and ribavirin is su-perior to group B in SVR rate.