| 早产儿视网膜病变研究新进展 |
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| 引用本文： | 许晓璇,吴雅俊,吴红云,胡裕翔,程艺,晏立,饶杰,吴娜,吴晓蓉.早产儿视网膜病变研究新进展[J].中国医学科学院学报,2019,41(2):261-266. |
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| 作者姓名： | 许晓璇 吴雅俊 吴红云 胡裕翔 程艺 晏立 饶杰 吴娜 吴晓蓉 |
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| 作者单位： | 1.南昌大学第一附属医院眼科,南昌 3300062 赣州市人民医院眼科,江西赣州 341000 |
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| 基金项目： | 国家自然科学基金(81760179);国家自然科学基金(81360151);江西省自然科学基金(20171BAB205046);江西省卫计委科技计划项目(20185118);江西省卫生计生委中医药科研课题(2017A001);江西省教育厅重点项目(GJJ160033);江西省基层卫生适宜技术“星火推广计划”项目(20188007);江西省科技支撑计划项目(20141BBG70027);江西省教育厅科技计划项目(GJJ13147);江西省学位与研究生教育教学改革研究项目(JXYJG-2018-016);南昌大学研究生案例建设项目(9202-0210210802) |
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| 摘 要： | 早产儿视网膜病变是一种病理性新生血管增殖并伴纤维化改变的早产儿眼底疾病,是当前发展中国家和发达国家儿童可预防性失明的重要原因,其研究进展一直是眼科和儿科的临床关注热点。随着对早产儿视网膜病变发病机制更清晰的认知,其基础和临床研究日益增多,其抗血管内皮生长因子治疗及手术治疗方式较为成熟,同时多种治疗药物如胰岛素样生长因子-1、转化生长因子-β、多不饱和脂肪酸、β-肾上腺素受体阻滞剂等也取得一定进展,现就早产儿视网膜病变相关研究进展做一综述。
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| 关 键 词： | 早产儿视网膜病变 抗血管内皮生长因子 胰岛素样生长因子-1 转化生长因子-β 多不饱和脂肪酸 |
| 收稿时间： | 2018-09-23 |
Advances in Retinopathy of Prematurity |
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| XU Xiaoxuan,WU Yajun,WU Hongyun,HU Yuxiang,CHENG Yi,YAN Li,RAO Jie,WU Na,WU Xiaorong.Advances in Retinopathy of Prematurity[J].Acta Academiae Medicinae Sinicae,2019,41(2):261-266. |
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| Authors: | XU Xiaoxuan WU Yajun WU Hongyun HU Yuxiang CHENG Yi YAN Li RAO Jie WU Na WU Xiaorong |
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| Affiliation: | 1.Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China2 Department of Ophthalmology,Ganzhou People’s Hospital,Ganzhou,Jiangxi 341000,China; |
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| Abstract: | Retinopathy of prematurity(ROP)is a pathological neovascularization with fibrotic changes in the fundus of premature infants.It is a major cause of preventable blindness in children in both developing and developed countries.Treatment of ROP has long been a hot research topic in ophthalmology and pediatrics.With a clearer knowledge of the pathogenesis of ROP,more basic and clinical studies have been carried out.The anti-vascular endothelial growth factor therapy and surgical treatment have become mature strategies,and a variety of therapeutic drugs including insulin-like growth factor-1,transforming growth factor-β,polyunsaturated fatty acids,and β-adrenergic receptor blockers have been developed.This article reviews the recent advances in ROP. |
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| Keywords: | retinopathy of prematurity anti-vascular endothelial growth factor insulin-like growth factor-1 transforming growth factor-β polyunsaturated fatty acids |
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