| 中国妇女子宫颈癌细胞人乳头瘤病毒DNA的检测 |
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| 引用本文： | 高红,司静懿,李昆,韩日才,王申五,谷淑燕,曾毅,周宜男,王月珠.中国妇女子宫颈癌细胞人乳头瘤病毒DNA的检测[J].中国医学科学院学报,1988,10(4):276-278. |
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| 作者姓名： | 高红 司静懿 李昆 韩日才 王申五 谷淑燕 曾毅 周宜男 王月珠 |
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| 作者单位： | 协和医科大学，中国医学科学院基础医学研究所，中国医学科学院基础医学研究所，中国医学科学院基础医学研究所，中国医学科学院基础医学研究所，中国预防医学科学院病毒学研究所，中国预防医学科学院病毒学研究所，新疆医学院，新疆医学院 学生，北京，北京，北京，北京 |
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| 摘 要： | 使用DNA-DNA斑点杂交技术检测取自北京和新疆两地的40例人宫颈癌活检组织中HPV-16型和18型的DNA相关序列。以~(32)P-HPV-16及18为探针,前者杂交阳性率为75％(30/40),后者为17.5％(7/40)。初步表明,中国妇女宫颈癌的发生与HPV-16型关系密切。HPV-16型和18型的阳性率新疆地区高于北京地区,少数民族高于汉族,提示HPV感染似乎存在地理差异和民族差异。
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| 关 键 词： | 人乳头瘤病毒 斑点核酸杂交 |
Detection of Human Papilloma Virus DNA in Cervical Carcinoma Cells in Chinese Patients |
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| Gau Hong,et al.Detection of Human Papilloma Virus DNA in Cervical Carcinoma Cells in Chinese Patients[J].Acta Academiae Medicinae Sinicae,1988,10(4):276-278. |
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| Authors: | Gau Hong |
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| Affiliation: | Institute of Basic Medical Sciences. Beijing |
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| Abstract: | Forty biopsies of human squmous epithelial carcinoma of uterine cervix were detected with DNA hybridization for human papillomavirus (HPV) type 16 and 18 DNA sequences in Beijing and Xinjiang. Results showed that 75% (30/40) of speciments were positive for HPV-16, and 17.5% (7/40) positive for HPV-18, the positive rate for HPV-16 and HPV-18 being higher in Xinjiang than that in Beijing. Besides, the positive rate for HPV-16 and HPV-18 were also higher in minorities than in Hans. It is possible that the difference is due to different custom and habit in different geographic regions and races. |
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| Keywords: | human papilloma virus DNA dot blot hybridization |
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