血清CA242与CEA联合检测对消化系恶性肿瘤的诊断价值

为了探讨血清CA2 4 2与癌胚抗原 (CEA)联合检测对消化系恶性肿瘤的诊断价值 ,应用间接ELISA法测定消化系恶性肿瘤患者 (n =95)血清CA2 4 2与CEA ,并与消化系良性疾病患者 (n =90 )和健康体检者 (n =30 )进行对照。结果显示 ,CA2 4 2与CEA在肿瘤组的检出率分别为 4 3.1 6%和 4 5.2 6% ,均明显高于 2个对照组 (P均 <0 .0 1 )。两者联合检测的总检出率为 62 .1 1 % ,特异性为 73.55% ,高于各单项检测 (P <0 .0 1 )。其中大肠癌、胃癌、肝癌、胰腺癌敏感性由高至低依次为 72 .4 1 %、69.2 3%、57.1 4 %、55.56% ,均显著高于食管癌 1 8.1 8% (P <0 .0 1 )。提示 :血清CA2 4 2与CEA联合检测可以提高对消化系恶性肿瘤诊断的敏感性 ,该方法对消化系腺癌类肿瘤诊断具有一定应用价值

Clinical Evaluation of Combined Serum Tumor Markers (CA242 and CEA) in the Diagnosis of Gastrointestinal Malignant Tumor

In order to evaluate combined serum tumor markers in the diagnosis of gastrointestinal malignant tumor, serum CA242 and CEA were concomitantly determined by ELISA in 95 patients with gastrointestinal malignant tumor, 90 patients with benign diseases and 30 healthy blood donors. In general, serum CA242 and CEA levels were increased more significantly in malignant tumor group than in the other two groups. The sensitivities of CA242 and CEA in gastrointestinal malignant tumor were 43.16% and 45.26% respectively, while the combined markers was 62.11%, which was significantly higher than either of the one marker(P<0.01). The specificity of the combined markers was 73.55% including colon tumors(72.41%), gastric carcinoma(69.23%), hepatic carcinoma (57.14%), pancreatic carcinoma (55.56%), which were all much higher than esophageal carcinoma(18.18%). These data suggest that the combined determination of serum CA242 and CEA can increase the sensitivity in diagnosis of gastrointestinal malignant tumors.