| WIP1对小鼠B细胞及T细胞发育的影响 |
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| 引用本文： | 陈陟阳,张俊伶,马小茗,易微微,陈显达,石桂英,鞠振宇.WIP1对小鼠B细胞及T细胞发育的影响[J].中国比较医学杂志,2011,21(6):52-59. |
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| 作者姓名： | 陈陟阳 张俊伶 马小茗 易微微 陈显达 石桂英 鞠振宇 |
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| 作者单位： | 中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021 |
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| 基金项目： | 实验血液学国家重点实验室开放课题 |
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| 摘 要： | 目的研究WIP1基因对小鼠骨髓B细胞发育及胸腺T细胞发育的影响。方法流式细胞术测定小鼠骨髓B细胞及胸腺T细胞发育中各阶段的细胞比例。结果虽然WIP1缺失小鼠骨髓B细胞发育各阶段比例正常,但骨髓总体B细胞比例下降;WIP1基因敲除小鼠胸腺发育障碍,CD8/CD4双阴性细胞比例增高,CD8/CD4双阳性细胞比例降低。结论 WIP1基因在小鼠骨髓B细胞及胸腺T细胞的发育过程中起重要作用。
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| 关 键 词： | WIP1 基因敲除小鼠 B细胞 T细胞 |
The Role of WIP1 in Mouse B cell and T cell Development |
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| CHEN Zhi-yang,ZHANG Jun-ling,MA Xiao-ming,YI Wei-wei,CHEN Xian-da,SHI Gui-ying,JU Zhen-yu.The Role of WIP1 in Mouse B cell and T cell Development[J].Chinese Journal of Comparative Medicine,2011,21(6):52-59. |
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| Authors: | CHEN Zhi-yang ZHANG Jun-ling MA Xiao-ming YI Wei-wei CHEN Xian-da SHI Gui-ying JU Zhen-yu |
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| Affiliation: | CHEN Zhi-yang,ZHANG Jun-ling,MA Xiao-ming,YI Wei-wei,CHEN Xian-da,SHI Gui-ying,JU Zhen-yu(Key Laboratory of Human Disease Comparative Medicine,Ministry of Heath,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences & Peking Union Medical College,Human Disease Animal Models Level-3 Laboratory of State Administration of Traditional Chinese Medicine,Beijing 100021,China) |
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| Abstract: | Objective To study the role of WIP1 gene in mouse B cell and T cell development.Methods The proportion of the B cell in bone marrow and T cell in the thymus were determined by the flow cytometry.Results Although the proportion of different subsets in B cell development was normal,the total number of B cell in bone number was decreased.WIP1 gene knockout mice had defect in thymus development,the proportion of CD8/CD4 double negative cells was increased,but the CD8/CD4 double positive cells was decreased.Conc... |
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| Keywords: | WIP1 |
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