| RELATIONSHIP AMONG MYOCARDIAL INFARCTION, INSERTION／DELETION POLYMORPHISM OF FVII GENE PROMOTER REGION AND FVII ACTIVITY |
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| 引用本文： | 陶蓉,于金德,陆林,乐玮,尤蓓,陈颖,龚兰生,曹文俊,黄薇,朱鼎良.RELATIONSHIP AMONG MYOCARDIAL INFARCTION, INSERTION／DELETION POLYMORPHISM OF FVII GENE PROMOTER REGION AND FVII ACTIVITY[J].上海第二医科大学学报,2004,16(1):18-21. |
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| 作者姓名： | 陶蓉 于金德 陆林 乐玮 尤蓓 陈颖 龚兰生 曹文俊 黄薇 朱鼎良 |
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| 作者单位： | Department of Cardiology，Ruijin Hospital，SSMU，Shanghai 200025，China，Department of Cardiology，Ruijin Hospital，SSMU，Shanghai 200025，China，Department of Cardiology，Ruijin Hospital，SSMU，Shanghai 200025，China，Department of Cardiology，Ruijin Hospital，SSMU，Shanghai 200025，China，Department of Cardiology，Ruijin Hospital，SSMU，Shanghai 200025，China，Department of Cardiology，Ruijin Hospital，SSMU，Shanghai 200025，China，Department of Cardiology，Ruijin Hospital，SSMU，Shanghai 200025，China，Shanghai Institute of Hematology，Ruijin Hospital，SSMU，Shanghai 200025，China，Shanghai Institute of Hematology，Ruijin Hospital，SSMU，Shanghai 200025，China，Shanghai Institute of Hypertension，SSMU，Shanghai 200025，China |
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| 基金项目： | Supported by the Scientific and Technological Committee of Shanghai (974119003) |
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| 摘 要： | Objective To explore the relationship among myocardial infarction (MI) , promoter regionpolymorphism of FVII gene and FVII activity in a Chinese population. Methods Denaturing gradient gel electro-phoresis technique was used to study promoter region polymorphism of FVII gene, and plasma FVII activity (FVIIC) was examined by one stage clotting assay in 74 cases with MI as well as 123 normal controls. Results An insertion/deletion polymorphism of 10bp was found in the promoter region. Plasma FVII activity was significantly higher in the myocardial infarction (P <0. 05). Conclusion Elevated FVII activity may be a risk factor for myocardial infarction. There is no correlation found between the insertion/deletion polymorphism of FVII gene promoter region and myocardial infarction in a Chinese population (74 MI cases and 123 normal controls).
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| 关 键 词： | FVII基因 基因多态性 心肌梗死 聚合酶链反应 作用机制 临床意义 |
RELATIONSHIP AMONG MYOCARDIAL INFARCTION,INSERTION/DELETION POLYMORPHISM OF FVII GENE PROMOTER REGION AND FVII ACTIVITY |
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| TAO Rong YU Jin-de,LU Lin LE Wei YOU Bei CHEN
Ying GONG Lan-sheng.RELATIONSHIP AMONG MYOCARDIAL INFARCTION,INSERTION/DELETION POLYMORPHISM OF FVII GENE PROMOTER REGION AND FVII ACTIVITY[J].Journal of Shanghai Second Medical University(Foreign Language Edition),2004,16(1):18-21. |
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| Authors: | TAO Rong YU Jin-de LU Lin LE Wei YOU Bei CHEN
Ying GONG Lan-sheng |
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| Affiliation: | TAO Rong YU Jin-de,LU Lin LE Wei YOU Bei CHEN
Ying GONG Lan-sheng
Department of Cardiology,Ruijin Hospital,SSMU,Shanghai 200025,China
CAO Wen-jun,HUANG Wei
Shanghai Institute of Hematology,Ruijin Hospital,SSMU,Shanghai 200025,China
ZHU Ding-liang
Shanghai Institute of Hypertension,SSMU,Shanghai 200025,China |
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| Abstract: | Objective To explore the relationship among myocardial infarction (MI) , promoter region
polymorphism of FVII gene and FVII activity in a Chinese population. Methods Denaturing gradient gel electro-phoresis technique was used to study promoter region polymorphism of FVII gene, and plasma FVII activity (FVIIC) was examined by one stage clotting assay in 74 cases with MI as well as 123 normal controls. Results An insertion/deletion polymorphism of 10bp was found in the promoter region. Plasma FVII activity was significantly higher in the myocardial infarction (P <0. 05). Conclusion Elevated FVII activity may be a risk factor for myocardial infarction. There is no correlation found between the insertion/deletion polymorphism of FVII gene promoter region and myocardial infarction in a Chinese population (74 MI cases and 123 normal controls). |
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