THE PRODUCTION OF INTERLEUKIN-2 BY PERIPHERAL BLOOD MONONUCLEAR CELLS OF HEPATITIS B PATIENTS AND ITS CLINICAL SIGNIFICANCE |
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作者姓名: | 王萌 陆志檬 王耆煌 戴祥章 |
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摘 要: | The activity of IL-2 produced by activated PBMC in 25 hapatitis B patients including fulminant hepatitis (FH, 6 cases), acute hepatitis (AH, 4 cases), chronic active hepatitis (CAH, 6 cases) and chronic persistent hepatitis (CPH, 9 cases) as well as 11 normal controls was assayed by using splenoblasts as the responding cells. The results showed: (1) The IL-2 activity of all the 25 hepatitis patients were significantly lower than that of 11 normal controls and was lowest in FH patients (P<0.001); (2) The IL-2 activity was correlated with the SGPT activity dynamically in CPH patients (r=-0.4260, P<0.05); (3) The IL-2 activity of hepatitis B patients was related to the positive or negative state of anti-HBc-IgM (P<0. 05); (4) It was the function rather than the number of PBMC that paralleled the IL-2 activity (r<0.3, P>0.05).
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THE PRODUCTION OF INTERLEUKIN-2 BY PERIPHERAL BLOOD MONONUCLEAR CELLS OF HEPATITIS B PATIENTS AND ITS CLINICAL SIGNIFICANCE |
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Abstract: | The activity of IL-2 produced by activated PBMC in 25 hapatitis B patients including fulminant hepatitis (FH, 6 cases), acute hepatitis (AH, 4 cases), chronic active hepatitis (CAH, 6 cases) and chronic persistent hepatitis (CPH, 9 cases) as well as 11 normal controls was assayed by using splenoblasts as the responding cells. The results showed: (1) The IL-2 activity of all the 25 hepatitis patients were significantly lower than that of 11 normal controls and was lowest in FH patients (P<0.001); (2) The IL-2 activity was correlated with the SGPT activity dynamically in CPH patients (r=-0.4260, P<0.05); (3) The IL-2 activity of hepatitis B patients was related to the positive or negative state of anti-HBc-IgM (P<0. 05); (4) It was the function rather than the number of PBMC that paralleled the IL-2 activity (r<0.3, P>0.05). |
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Keywords: | viral hepatitis B interleukin-2 anti-HBc-IgM SGPT |
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