泼尼松联合胸腺肽α1治疗原发性肾病综合征的临床观察

目的观察泼尼松联合胸腺肽α1治疗原发性肾病综合征的临床疗效。方法 52例原发性肾病综合征患者随机分为治疗组和对照组,每组26例,均以泼尼松等综合治疗为主,治疗组在常规治疗的同时加用胸腺肽α1治疗,比较两组治疗前后临床症状的改善情况,血清免疫球蛋白(IgG、IgM、IgA)、补体(C3、C4)、高敏C反应蛋白(hs-CRP)、白介素(IL)-6、肿瘤坏死因子(TNF-α)水平以及尿蛋白定量的变化及复发率。结果治疗组血清免疫球蛋白IgG、补体C3水平升高,血清hs-CRP、IL-6、TNF-α及尿蛋白水平下降,与治疗前及对照组治疗后相比,差异有统计学意义(P<0.05);治疗组缓解率明显高于对照组,差异有统计学意义(P<0.05)。治疗6个月及12个月后,治疗组复发率低,明显优于对照组(P<0.05)。结论胸腺肽α1能有效平衡机体免疫功能,减轻炎性反应,联合泼尼松治疗原发性肾病综合征可显著提高缓解率,并能有效减少复发。

Treatment of primary nephrotic syndrome with prednisone and thymic-peptide α1

Objective To investigate the effect of prednisone combined with thymic-peptide α1 in patients with pri- mary nephrotic syndrome （PNS）. Methods 52 hospitalized patients of PNS were randomly divided into intervention group （n=26） and control group （n=26）. Both of them were given the comprehensive treatment （prednisone）. The patients of intervention group were also given thymic-peptide α1. The level of serum immunoglobulin （IgG, IgM, IgA）, complement（C3, C4） ,high sensitive C-reactive pretein （hs-CRP）, interle-ukin-G（IL-6）, tumornecrosis factor-α（TNF-α）, proteinuria and the relapse rate were compared before and after the therapy in each group. Results The levels of serum IgG, C3 increased and hs-CRP, IL-6, TNF-α, proteinuria decreased （P〈0.05）. Compared with the levels of those in the control group after treatment, there were significant differences in the intervention group （P〈0.05）. The effect in the intervention group was better than that of in control group（P〈0. 05）. 6 months and 12 months after treatment, the relapse rate was significantly lower in the intervention group than that of the control group（P〈0. 05）. Conclusion Thy- mie-peptideα1 can regulate immunity effectively, decrease inflammatory reaction. Combined with prednisone can enhance observably clinical curative effects in patients with PNS and reduce the recurrence.