疼痛、抑郁与癌症患者生活质量的调查分析

目的:总结癌症患者疼痛和抑郁的发生率,分析癌痛与肿瘤患者抑郁发生的相关性,探讨癌痛和抑郁对癌症患者生活质量的影响.方法:收集236例癌症患者的相关资料,采用癌症生活质量自评量表FACT-G、抑郁自评量表(SDS)、疼痛数字分级法(NRS)以及一般状况评定量表分析资料,采用单因素方差分析和线性回归分析法分析各因素的相关性.结果:236例经病理确诊的癌症患者疼痛的发生率为65.3%,轻、中度痛占57%,重度痛占8.3%;抑郁的发生率为34.3%.疼痛与肿瘤患者抑郁的发生明显相关(R2=0.473,P<0.001).不同疼痛程度的患者之间其身体状况、情感状况和功能状况评分均有显著差异(P=0.001, 0.047, 0.008);而有、无抑郁患者之间的身体状况,情感状况和功能状况也有显著差异(P=0.001,0.025, 0.002).结论:癌症患者的疼痛与抑郁的发生密切相关,两者对患者的生活质量均产生重要影响.

Effects of depression and pain on quality of life in cancer patients: a survey analysis

Objective:To study the morbidity of pain and depression, the effects of depression and pain on quality of life, and the relationship between pain and depression in cancer patients.Methods: All the 236 patients were inpatients. The functional Assessment of Cancer Therapy-General questionnaire, the Self-Rating Depression Scale (SDS), numerical rating scale and self-designed general condition questionnaire were used to collect the data of patients. Data were analyzed with ANOVA and linear regression analysis.Results: It was found that the morbidity of pain was 65.3%(154/236), of whom 135 patients had mild and moderate pain, and 19 had severe pain. The morbidity of depression was 34.3%(81/236). Pain was significantly correlated with the development of depression in cancer patients(R2=0.473,P<0.001). The physical,mental and functional well-being of patients with different degrees of pain was significantly different(P=0.001,0.047,0.008); the same was true of patients with or without depression(P=0.001,0.025,0.002).Conclusion: Depression in cancer patients is closely related with the presence of pain; both pain and depression have great influence on quality of life in cancer patients.