大剂量重组人红细胞生成素治疗尿毒症贫血的疗效观察

目的：观察每周1次大剂量皮下注射国产重组人红细胞生成素（rhEPO)治疗尿毒症贫血的临床疗效。方法：20例尿毒症合并肾性贫血的血透患，随机分为2组，试验组10例，采用国产rhEPO（益比奥，沈阳三生制药公司10000U皮下注射1次／周治疗；对照组10例，采用进口rhEPO（利血宝，日本麒麟公司）3000U皮下注射2－3次／周治疗。治疗期间，监测血常规，血脂，肝肾功能，电解质，血压等指标及患出现的各种不良反应。结果：试验组显效5例，有效4例，无效1例，对照组显效6例，有效3例，无效1例，治疗前后白细胞，血小板，血脂，肝肾功能，电解质无明显变化。结论：大剂量益比奥每周1次治疗肾性贫血安全可靠，疗效确切，不良反应发生率与利血宝相似，且价格／药效明显低于利血宝。

High dose of rhEPO in treatment of uremic anemia

Objective: To evaluate the clinical effect of high dose of rhEPO on uremic anemia by subcutaneous injection once a week. Methods: Twenty anemic patients on maintenance hemodialysis were divided into 2 groups at random. Ten patients in treatment group accepted 10 000 U of rhEPO (Shenyang Sunshine Pharmaceutical Co. Ltd. ) through subcutaneous injection once a week. Ten patients in control group accepted 3 000 U of EPO (Kirin Kunpeng Bio-pharmaceutical Co. Ltd. ) through subcutaneous injection twice to 3 times a week. Routine blood test,liver and kidney function,electrolyte,blood pressure and side effects were observed. Results: The obvious effective,effective and ineffective cases in treatment group were 5, 4 and 1 respectively and 6,3 and 1 in control group respectively. The pre- and post-treatment liver and kidney function,electrolyte, blood pressure and side effects of the 2 groups had no significant changes. Conclusion: Treatment of uremic anemia with high dose of rhEPO is effective and safe. The side effect of rhEPO is similar in 2 groups. The cost/effect of rhEPO in treatment group is significantly lower than that in control group.