上海市脑血管病危险因素的前瞻性研究——三年随访资料的单因素分析

本文报告了上海市18个里委15885人脑血管病危险因素前瞻性队列研究1987—1990年(36216人年)随访的结果。用单因素分析的方法分析了几种因素和脑卒中之间的关系,发现高血压病家族史(相对危险度,RR=5.18),高血压病史(RR=4.14),现症高血压(RR=5.14).心脏病(RR=3.22),糖尿病(RR=4.64)和肥胖(RR=2.01),是明显的脑卒中危险因素。血清高密度脂蛋白(HDL)增高,对出血性脑卒中似有一定的危险作用(RR=1.69),而HDL降低则对脑卒中似有一定的保护作用(RR=0.74)。对出血和缺血性脑中风的分别分析以及按性别分层分析发现,实测舒张期血压升高(≥21.28kPa)对出血性和缺血性脑卒中的危险度男(RR=5.48)和女性(RR=4.22)均较高,而对出血性脑卒中仅在男性是危险因素(RR=6.22),在女性无意义(RR=0.9,P>0.05)。糖尿病仅对缺血性脑卒中有危险性,在男性RR值为16.66,在女性RR值为12.76,而和出血性脑卒无联系。吸烟仅在女性为出血性和缺血性脑卒中的危险因素,RR值分别为1.80和2.47,而在男性则不显著。血清甘油三酯升高对女性的出血和缺血性脑卒中似有保护作用(RR=0.55),但不显著(P>0.05)。男女性血清HDL降低均为出血性脑卒中的保护因素,其RR值分别为0.32和0.47,但HDL增高在男性为出血性脑卒中的危险因素(RR=3.48),任缺血性脑卒中则正好

A Prospective Study on the Risk Factors of Cerebrovascular Diseases in Shanghai: Analysis of Single-factor of Follow-up Data for Three Years

In order to undersdand the risk factors of cerebrovascular diseases in residents of big cities a prospective Cohort study was carried out in 18 neighbourhoods in Shanghai. The paper re ports the results of 15885 people(36216 person - years) followed up from 1987 to 1990.Relationships between several factors and stroke were analysed using the method of single-factor analysis. It was found that family history of hypertension (RR- 5.18), history of hypertension. 1(RR=4.14), present high blood pressure (RR= 5.14), heart diseases (RR=3.22), diabetes (RR=4. 64) and obesity (RR=2.01) were risk factors for stroke. Higher high density lipoprotein (HDL) had some risk effects (RR= 1.69) for hemorrhagic stroke, but lower HDL had some protective effects (RR = 074) for stroke.Relationships between hemorrhagic stroke and ischemic stroke and some factors were analysed respectively, and analysed in layers by sex. It was found that present high diastolic blood pressure (>21.28 kPa)was a risk factor in hemorrhagic stroke and ischemic stroke for man (RR= 548) and woman (RR = 4.12), but that was a risk factor only in man(RR = 6.22) for hemorrhagic stroke.and had no significance in woman (RR=0.9). Diabetes was a risk factor in ischemic stroke for both man (RR= 16.66) and woman (RR= 12.76), but had no significance in hemorrhagic stroke. Smoking had a risk in woman for hemorrhagic stroke (RR=1.80) and ischemic stroke (RR = 2.47), but had no risk in man. Higher triglyceride might be a protective factor in hemorrhagic stroke for woman (RR = 0.55). Lower HDL in sera had protective effects in hemorrhagic stroke in both man (RR=0.32) and woman (RR = 0.47), but higher HDL in sera in man was a risk factor (RR = 3.48) for hemorrhagic stroke. Conversely in ischemic stroke, higher HDL in sera was a protective factor in man (RR = 0.33). The obesity and overweight had some risk effects in both hemorrhagic and ischemic stroke.