| 性早熟儿童IGF—Ⅰ和IGFBP—3水平的观察 |
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| 引用本文： | 王秀娣,留佩宁,项如莲.性早熟儿童IGF—Ⅰ和IGFBP—3水平的观察[J].温州医学院学报,2001,31(3):145-146. |
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| 作者姓名： | 王秀娣 留佩宁 项如莲 |
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| 作者单位： | 1. 温州医学院妇科内分泌研究室,
2. 温州医学院附属儿童医院儿科, |
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| 基金项目： | 温州市科委课题(KW980013)。 |
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| 摘 要： | 目的：通过对胰岛素生长因子－Ⅰ（IGF－Ⅰ）、胰岛素生长因子结合蛋白－3（IGFBP－3）、生长激素（GH）及雌二醇（E2）的检测，观察性早熟儿童的生长发育轴系发育情况及与性激素的关系。方法：分别对42例真性性早熟、14例正常儿童用放射免疫及免疫放射法检测GH、IGF－Ⅰ、IGFBP－3及E2水平。结果：真性性早熟组IGF-Ⅰ、IGFBP－3及E2水平与对照组7比较差异均有非常显性意义（P＜0.01）；GH水平高于对照组，但无统计学意义（P＞0.05）。将观察组IGF－Ⅰ、IGFBP－3、GH与E2值行相关分析，结果E2与IGF－Ⅰ及IGFBP-3均有非常显的相关性（P＜0.01），E2与GH无相关关系（P＞0.05），IGF-Ⅰ与IGFBP－3比较有显的相关性（P＜0.05）。结论：性早熟儿童生长激素介质IGF－Ⅰ、IGFBP－3水平显升高，IGF－Ⅰ、IGFBP－3的升高与E2水平有密切的关系。
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| 关 键 词： | 真性性早熟 IGF－Ⅰ IGFBP－3 生长激素 儿童 |
| 文章编号： | 1000-2138(2001)03-0145-02 |
| 修稿时间： | 2001年1月2日 |
The observation of serum
IGF- |
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| WANG Xiu-Di,LIU Pei-ning,XIANG Ru-lian.The observation of serum
IGF-[J].Journal of Wenzhou Medical College,2001,31(3):145-146. |
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| Authors: | WANG Xiu-Di LIU Pei-ning XIANG Ru-lian |
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| Affiliation: | WANG Xiu Di,LIU Pei ning,XIANG Ru lian.* Department of Gynecological Edocrinology,Wenzhou Medical College,Wenzhou 325027. |
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| Abstract: | Objective：To observe the correlation between the growing-hormone axis and the sex hormone in sexual precocity by measuring the levels of IGF-Ⅰ、IGFBP-3、 GH and E2.Methods：The levels of IGF-Ⅰ、 IGFBP-3 、GH、 E2 were detected with Radioammunoassay. 42 cases of sexual precocity children were taken as the observation group,14 cases normal children as the control group.Results：The mean of IGF-Ⅰ、IGFBP-3、 E2、 GH was 293.30ng/ml、 5145.00ng/ml、10.15pg/ml、4.27ng/ml in the observation group and was 77.27ng/ml、2198.50ng/ml、3.50pg/ml 、2.33ng/ml in the control group.The levels of IGF-Ⅰ 、IGFBP-3、 E2 were significantly different between observation group and control group.There was significant correlation between IGF-Ⅰ、 IGFBP-3 and E2 in observation group, and no correlation between GH and E2.Conclusion：The levels of IGF-Ⅰ、IGFBP-3 were significantly higher in the sexual precocity children.there was significantly correlation between IGF-Ⅰ、IGFBP-3 and E2. |
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