| miRNA-223在肝癌中的研究进展 |
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| 引用本文： | 张蕾,龚泽众,李岩.miRNA-223在肝癌中的研究进展[J].大连医科大学学报,2019,41(3):272-276. |
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| 作者姓名： | 张蕾 龚泽众 李岩 |
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| 作者单位： | 大连医科大学第二临床学院,辽宁大连,116044;大连医科大学解剖教研室,辽宁大连,116044 |
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| 摘 要： | 内源性非编码小分子miRNA-223可作用于靶基因调控肝癌的发生发展，对肝癌细胞增殖、迁移、侵袭、凋亡以及耐药等生物学功能产生影响。血清与肿瘤中miRNA-223的表达水平对肝癌的诊断与治疗具有一定的参考价值，是肝癌诊断、治疗以及判断预后潜在的生物标志物。本文对近年来miRNA-223在肝癌中的研究进展作一综述。
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| 关 键 词： | 肝癌 miRNA-223 IGF-IR STMN1 NLRP3 整合素αV亚基 |
| 收稿时间： | 2018/12/6 0:00:00 |
Research advance of miRNA-223 in hepatocellular carcinoma |
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| ZHANG Lei,GONG Zezhong and LI Yan.Research advance of miRNA-223 in hepatocellular carcinoma[J].Journal of Dalian Medical University,2019,41(3):272-276. |
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| Authors: | ZHANG Lei GONG Zezhong and LI Yan |
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| Abstract: | MiRNA-223 is a kind of endogenous small non-coding RNA, which has been shown to regulate the progression of hepatocellular carcinoma by targeting tumor suppressor or oncogenes. It plays a key role in cell proliferation, migration, invasion and drug resistance of hepatocellular carcinoma cell. The expression level of miRNA-223 in serum and liver tissues provides important reference value for the diagnosis and treatment of hepatocellular carcinoma, which makes miRNA-223 a potential biomarker for diagnosis, treatment and prognosis of hepatocellular carcinoma in clinic. We reviewed the research progress of microRNA223 in hepatocellular carcinoma in recent years. |
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