| 回肠Na^＋／胆汁酸转运体与高脂血症关系的研究 |
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| 引用本文： | 冯俊,赵平武,罗亮,贺凯,李波,夏先明.回肠Na^＋／胆汁酸转运体与高脂血症关系的研究[J].泸州医学院学报,2011,34(6):640-643. |
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| 作者姓名： | 冯俊 赵平武 罗亮 贺凯 李波 夏先明 |
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| 作者单位： | 1. 绵阳市中心医院普外科,四川绵阳,621000
2. 泸州医学院附属医院肝胆外科 |
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| 基金项目： | 四川省卫生厅科学研究项目(NO:070269) |
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| 摘 要： | 目的：探讨回肠Na^＋／胆汁酸性转运体（IBAT）基因表达与高脂血症形成的相关性。方法：取Wistar雄性大鼠60只随机分为2组：普通饮食组（对照组）、高脂饮食组（实验组）。喂养13周后分别提取对照组和实验组wistar大鼠的空肠末端、回肠末端、盲肠、结肠近端组织，应用RT—PCR和免疫SP法分别检测2组模型Wistar大鼠的空肠末端、回肠末端、盲肠、结肠近端组织的IBAT基因表达强度；对所得结果进行统计分析。结果：IBAT基因表达：结肠近端在对照组和实验组均无表达，空肠末端、回肠末端、盲肠表达实验组强于对照组（P〈0．05）。结论：实验组的IBAT表达升高，引起体内胆酸池增大和肝内胆固醇含量升高，从而引起血清胆固醇增加，加速高脂血症的形成。
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| 关 键 词： | 回肠Na^＋／胆汁酸转运体 高脂血症 胆汁酸循环 |
RELATIONSHIP BETWEEN THE EXPRESSION OF ILEAL NA~+/BILE ACID TRANSPORTER(IBAT) AND HYPERLIPIDEMIA |
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| Feng Jun,et al.RELATIONSHIP BETWEEN THE EXPRESSION OF ILEAL NA~+/BILE ACID TRANSPORTER(IBAT) AND HYPERLIPIDEMIA[J].Journal of Luzhou Medical College,2011,34(6):640-643. |
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| Authors: | Feng Jun |
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| Affiliation: | Feng Jun,et al Department of Gastrointestinal Surgery,the Central Hospital of Mianyang |
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| Abstract: | Objective:To explore the relationship between the expression of ileal Na+/ bile acid transporter(IBAT)and hyperlipidemia.Methods:Sixty male Wistar rats were randomly divided into normal control diet(n=30) and high fat diet groups(n=30).Distal ileum,distal jejunum,cecal and proximal colon specimens were obtained 13 weeks after feeding.The expression of IBAT was determined by real-time PCR,and streptavidin-perosidase method was adopted for immunohistochemical staining.Results:The expressions of IBAT in distal... |
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| Keywords: | Ileal Na / bile acid transporter Hyperlipidemia Bile acid cycle |
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