COMT基因多态性与精神分裂症发病风险及其临床特征的相关性研究

目的探讨儿茶酚氧位甲基转移酶(COMT)的基因多态性与精神分裂症发病风险及临床特征之间的相关性。方法采用病例-对照研究设计,按照CCMD-3诊断标准,在中国汉族人群中收集83例首发精神分裂症患者和65例正常对照进行研究。运用阳性与阴性症状评定量表(PANSS)评定精神症状,运用聚合酶链式反应-限制性片段长度多态分析(PCR-RFLP)的方法对研究对象进行基因分型。结果两组COMT基因Val158/108Met多态性等位基因及基因型频率差异均有统计学意义(均<0.05);另外,COMT基因多态性也与精神分裂症患者年龄、病程相关联。结论 COMT基因Val158/108Met多态性可能是精神分裂症的易感因素之一,与精神分裂症患者年龄、病程相关联。

COMT polymorphism in schizophrenia onset risk and its correlation with clinical features

Objective To investigate the association between catechol-O-methyhransferase (COMT) gene polymorphism and both of schizophrenia onset risk and clinical feature.Methods Case control study was used and a total of 83 Chinese Han schizophrenic patients and 65 healthy comparison subjects were recruited in this study. All patients were examined by trained psychiatrists using the Chinese Classification of Mental Disorders (CCMD-3) criteria. The psychiatric symptom was evaluated by using the positive and negative syndrome scale (PANSS). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for COMT genotypes determined. Results The difference of genetic influences between schizophrenia patients and health control in the COMT Val158Met genotype distributions was obtained (P=0.038). The Val allele in patients was obviously higher than that in control in genotype frequencies analysis (P=0.008). In addition, the COMT polymorphism was relative to age and disease course. Conclusions COMT polymorphism may be a susceptive factor for the development of schizophrenia and is relative to age and disease course of schizophrenia.